The following drugs, biologics (e.g., vaccines, therapeutic antibodies), or foods are listed in Evaluations of Drug Interactions 2003 as causing “highly clinically significant” or “clinically significant” interactions when used together with any of the drugs in this section. In some sections with multiple drugs, the interaction may have been reported for one but not all drugs in this section, but we include the interaction because the drugs in this section are similar to one another. We have also included potentially serious interactions listed in the drug’s FDA-approved professional package insert or in published medical journal articles. There may be other drugs, especially those in the families of drugs listed below, that also will react with this drug to cause severe adverse effects. Make sure to tell your doctor and pharmacist the drugs you are taking and tell them if you are taking any of these interacting drugs:
At least two weeks should elapse after you stop taking a monoamine oxidase (MAO) inhibitor and before you start taking bupropion. The same is true if you stop taking bupropion and then start one of these MAO inhibitors: deprenyl, ELDEPRYL, EUTONYL, furazolidone, FUROXONE, isocarboxazid, MARPLAN, MATULANE, NARDIL, PARNATE, phenelzine, procarbazine, selegiline, tranylcypromine.
AVENTYL, carbamazepine, cyclophosphamide, CYTOXIN, desipramine, digoxin, DILANTIN, flecainide, fluoxetine, HALDOL, haloperidol, imipramine, LANOXIN, LOPRESSOR, MELLARIL, metoprolol, NORFLEX, NORPRAMINE, nortriptyline, orphenadrine, paroxetine, PAXIL, phenobarbital, phenytoin, propafenone, PROZAC, RISPERDAL, risperidone, RYTHMOL, sertraline, TAMBOCOR, TEGRETOL, thioridazine, TOFRANIL, ZOLOFT.
Taking bupropion with other drugs that also affect the central nervous system adds to adverse effects, including risk of seizures: alcohol, amitriptyline, chlorpromazine, clozapine, CLOZARIL, DESYREL, ELAVIL, fluoxetine, HALDOL, haloperidol, lithium, LITHOBID, LITHONATE, loxapine, LOXITANE, LUDIOMIL, maprotiline, meclobemide, MOBAN, molindone, NAVANE, NORVIR, pargyline, PROZAC, ritonavir, thiothixene, THORAZINE, trazodone.