The following drugs, biologics (e.g., vaccines, therapeutic antibodies), or foods are listed in Evaluations of Drug Interactions 2003 as causing “highly clinically significant” or “clinically significant” interactions when used together with any of the drugs in this section. In some sections with multiple drugs, the interaction may have been reported for one but not all drugs in this section, but we include the interaction because the drugs in this section are similar to one another. We have also included potentially serious interactions listed in the drug’s FDA-approved professional package insert or in published medical journal articles. There may be other drugs, especially those in the families of drugs listed below, that also will react with this drug to cause severe adverse effects. Make sure to tell your doctor and pharmacist the drugs you are taking and tell them if you are taking any of these interacting drugs:
Metformin should be temporarily discontinued if you are undergoing a radiologic procedure that requires the use of an intravenous contrast product containing iodine.
The thiazide diuretics, or water pills, interact with metformin.
Other drugs that interact with metformin are: acetophenazine, ACTH, ADDERAL, ADVIR, AEROBID, albuterol, ALUPENT, amiloride, amlodipine, ARAMINE, ARMOUR THYROID, BACTRIM, beclomethasone, BECLOVENT, benzphetamine, bepridil, bitolterol, BRONKOSOL, CALAN, CARDENE, CARDIZEM, chloral hydrate, chlorpromazine, CHOLOXIN, cimetidine, COMPAZINE, corticotropin, cortisone, cosyntropin, COTROSYN, COVERA, DECADRON, DEPO-MEDROL, desoxycorticosterone, DEXADRINE, dexamethasone, dextroamphetamine, dextrothyroxine, DIDREX, diethylpropion, digoxin, DILACOR, DILANTIN, diltiazem, DIULO, dobutamine, DOBUTREX, DOCA, dofetilide, dopamine, DYNACIRC, DYRENIUM, ephedrine, epinephrine, ETRAFON, FASTIN, felodipine, flunisolide, fluphenazine, furosemide, hydrocortisone, indapamide, INH, isoetharine, isoniazid, isoproterenol, isradipine, ISUPRIL, LANOXIN, LASIX, levothyroxine, LOZOL, MAXIR, mazindol, MEDROL, mephentermine, mesoridazine, metaproterenol, metaraminol, methamphetamine, methdilazine, methylphenidate, methylprednisolone, metolazone, MIDAMOR, midodrine, morphine, NASALIDE, nicardipine, nimodipine, NIMOTOP, nisoldipine, NOCTEC, norepinephrine, NORVASC, oral contraceptives, orlistat, PERMITIL, perphenazine, PHENERGAN, phenmetrazine, phentermine, phenylephrine, phenytoin, piperacetazine, pirbuterol, PLENDIL, PRELUDIN, PROAMATINE, procainamide, PROCANBID, prochlorperazine, promethazine, PROVENTIL, pseudoephedrine, QUIDE, QUINAGLUTE, QUINIDEX, quinidine, quinine, ranitadine, RITALIN, ritodrine, salmeterol, SANOREX, SEREVENT, SERENTIL, STELAZINE, SUDAFED, SULAR, sulfamethoxazone-trimethoprim, SYNTHROID, TACRYL, TAGAMET, TENUATE, THORAZINE, thyroid, TIAZAC, TIKOSYN, TINDAL, TORNALATE, triameterene, trifluoperazine, VANCENASE, VANCERIL, VASCOR, verapamil, WYAMINE, XENICAL, YUTOPAR, ZANTAC.