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Drug Profile

The information on this site is intended to supplement and enhance, not replace, the advice of a physician who is familiar with your medical history. Decisions about your health should always be made ONLY after detailed conversation with your doctor.

Generic drug name: beclomethasone nasal steroid spray (bek low METH a sone)
Brand name(s): BECLOVENT, BECONASE AQ, QNASL, VANCENASE AQ, VANCERIL
GENERIC: not available FAMILY: Nasal Steroids
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Generic drug name: budesonide (byoo DES o nyde)
Brand name(s): BREZTRI AEROSPHERE, ENTOCORT EC, ORTIKOS, RHINOCORT AQUA, UCERIS
GENERIC: not available FAMILY: Nasal Steroids
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Generic drug name: fluticasone propionate nasal steroid spray (flue TIK a sone)
Brand name(s): FLONASE
GENERIC: not available FAMILY: Nasal Steroids
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Generic drug name: mometasone nasal steroid spray (mow MET a sone)
Brand name(s): NASONEX
GENERIC: not available FAMILY: Nasal Steroids
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Generic drug name: triamcinolone nasal steroid spray (try am SIN o lone)
Brand name(s): NASACORT ALLERGY 24 HOUR
GENERIC: not available FAMILY: Nasal Steroids
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Pregnancy and Breast-feeding Warnings [top]

Pregnancy Warning

Corticosteroids caused fetal death and fetal malformations in animal studies. Because of the potential for serious adverse effects to the fetus, these drugs should not be used by pregnant women.

Breast-feeding Warning

Corticosteroids are excreted in human milk. Because of the potential for adverse effects in nursing infants, you should not take these drugs while nursing.

Facts About This Drug [top]

Beclomethasone (BECLOVENT, BECONASE AQ, VANCENASE AQ, VANCERIL), budesomide (RHINOCORT AQUA), fluticasone (FLONASE), mometasone (NASONEX) and triamcinolone (NASACORT AQ) are nasal steroid sprays that control, but do not cure, rhinitis (inflammation in the nose). The effectiveness of these nasal sprays is similar.[1],[2],[3],[4],[5],[6]

Beclomethasone also is approved for prevention of nasal polyp regrowth after surgical removal.[7] Mometasone was approved by the Food and Drug...

Beclomethasone (BECLOVENT, BECONASE AQ, VANCENASE AQ, VANCERIL), budesomide (RHINOCORT AQUA), fluticasone (FLONASE), mometasone (NASONEX) and triamcinolone (NASACORT AQ) are nasal steroid sprays that control, but do not cure, rhinitis (inflammation in the nose). The effectiveness of these nasal sprays is similar.[1],[2],[3],[4],[5],[6]

Beclomethasone also is approved for prevention of nasal polyp regrowth after surgical removal.[7] Mometasone was approved by the Food and Drug Administration (FDA) in 2005 for the treatment of nasal polyps in patients 18 years of age and older.

Nasal sprays of steroids primarily reduce rhinitis due to allergies or unidentifiable causes.[8],[9],[10] Rhinitis may be seasonal or continuous. Nasal steroids also may reduce inflammation of the lower airway that can accompany symptoms of rhinitis in people with or without asthma.[11]Nasal steroids are not intended for the common cold.[12]

The first step to controlling rhinitis is to eliminate or avoid the cause of your allergies as much as possible. If this does not work, drugs may be tried. Antihistamines such as chlorpheniramine (ALERMINE, CHLOR-TRIMETON) relieve most symptoms, except nasal congestion. Antihistamines work just as well as nasal steroids to relieve eye symptoms.[13]

Adverse effects

Some of the nasal steroid is absorbed systemically and can cause suppression of adrenal gland function.[14],[15],[16] In severe cases, suppression of adrenal glands can cause low blood sugar, unconsciousness, convulsions, coma or death. Onset in adults may start with drowsiness and nausea. This can occur during fasting or if steroids are stopped abruptly.

When taken by mouth, steroids can suppress growth in children and adolescents, especially if high doses are used for long periods. Although short-term studies show minimal effect on growth and development, long-term studies are needed to determine the effect on final adult height.[17]

Steroids can reduce immunity, making you more prone to infections, and prolong healing of wounds. Avoid exposure to chickenpox or measles. A fungus, aspergillus, can develop and spread, leading to loss of vision or death.[18]

Sometimes, perforation of the nasal septum occurs — this is more common in women during the first few months of use. Avoid trauma with tip of nozzle on the septum.

Use of intranasal and inhaled corticosteroids can cause glaucoma and cataracts.[19]

The most frequently reported suspected adverse effect associated with inhaled corticosteroid use in children with asthma is behavior alteration, according to researchers from the Netherlands. Researchers have received reports of behavioral changes in children associated with the use of inhaled fluticasone propionate or salmeterol/fluticasone propionate.[20],[21]

The use of intranasal or inhaled corticosteroids appears to be associated with psychiatric disorders.[22],[23]

These products also have been associated with an increased risk of skin bruising and delayed healing.[24],[25]

Before You Use This Drug [top]

Do not use if you are:

  • pregnant or breastfeeding

Tell your doctor if you have or have had:

  • allergies, including to lactose
  • asthma
  • diabetes
  • glaucoma
  • herpes in the eye
  • infection (bacterial, fungal, parasitic, or viral)
  • liver problems
  • myocardial infarction (heart attack) or other heart problems
  • pregnancy or are breast-feeding
  • surgery, trauma, or ulcers of nose that are not yet healed, including nosebleeds
  • low thyroid (hypothyroidism)
  • tuberculosis
  • recent nasal ulcers, surgery, or trauma

Tell your doctor about any other drugs you take, including aspirin, herbs, vitamins, and other nonprescription products.

When You Use This Drug [top]

  • Request training on use of this drug from your doctor and read patient instructions carefully before use.
  • Avoid allergens that trigger your rhinitis.
  • Check with your doctor before getting any immunizations.
  • If you have excess nasal mucus or swelling of nose, use a vasoconstrictor for two to three days to enable the steroid to reach site of action.
  • It may take up to three weeks for full benefit.
  • Tell any doctor, dentist, emergency help, or pharmacist you see that you use a nasal steroid.

How to Use This Drug [top]

  • Follow specific use and cleaning instructions accompanying your device.
  • Shake well before each use.
  • Hold head in a neutral upright position.
  • Gently blow nose to clear of any thick or excessive mucus, if present.
  • Insert spray nozzle into the nose and toward the outer portion of the eye or the top of the ear on that side. If possible, use the right hand to spray the left nostril and left hand to spray the right nostril, to direct spray away from the septum.
  • Activate the device as recommended by the manufacturer and with the number of sprays recommended by your doctor.
  • Gently breathe in or sniff during the spraying.
  • Breathe out through the nose.
  • Avoid swallowing.
  • Do not spray in eyes.
  • Use drug at same time(s) each day. If you use more than once a day, schedule doses 12 hours apart.
  • If you miss a dose, take it if you remember it within an hour. Otherwise, wait until next regular dose. Do not take double doses.
  • Do not share your medication with others.
  • Store device at room temperature (canister does not work well if cold). Protect from light. Do not freeze. Keep out of reach of children for whom not prescribed.
  • Store budesonide with valve up; do not store in damp places.
  • Discard after the labeled number of actuations has been reached. Discard beclomethasone solution three months after opening package.
  • Do not transfer any remaining amount to another container. Any residual amount may not deliver the full dose.

Interactions with Other Drugs [top]

Evaluations of Drug Interactions 2003 lists no drugs, biologics (e.g., vaccines, therapeutic antibodies), or foods as causing “highly clinically significant” or “clinically significant” interactions when used together with the drugs in this section. We also found no interactions in the drug’s FDA-approved professional package inserts. However, as the number of new drugs approved for marketing increases and as more experience is gained with these drugs over time, new interactions may be discovered.

No studies have been done on interactions with fluticasone nasal spray. Manufacturers advise caution when budesonide or fluticasone is used with: ketoconazole, NIZORAL, NORVIR, ritonavir.

Manufacturers also advise caution when budesonide is used with: AZITHROMYCIN, clarithromycin, E-MYCIN, ERYBID, ERYTHROCIN, ERYC, ERY-TABS, erythromycin, ILOSONE, PCE.

Adverse Effects [top]

Call your doctor immediately if you experience:

  • breathing difficulty
  • tightness in chest
  • cough
  • dizziness or lightheadedness
  • ringing in ears
  • dry, irritated, painful, red, swollen, or watery eyes or eyelid, or discharge from eye
  • fever
  • flulike symptoms
  • headache
  • hoarseness
  • muscle pain
  • nausea or vomiting
  • nosebleed, blood in mucus, nasal burning, stinging, crusting, or dryness, irritation inside nose or stuffy nose, or sores or white patches inside nose
  • hives, itching, or rash
  • sore throat or white patches in throat
  • stomach pain
  • swelling of face, lips, or eyelids
  • unusual tiredness or weakness
  • vision blurs or blindness
  • wheezing

Call your doctor if these symptoms continue:

  • burning, dryness, or other irritation inside the nose (mild and transient)
  • sneezing attacks
  • stuffy nose or headache; throat discomfort

Signs of overdose:

  • acne
  • blurred vision
  • blood pressure increase
  • bone fracture
  • excess facial hair in women
  • impotence in men
  • menstruation changes
  • muscle wasting and weakness
  • excess fullness or rounding of face, neck, and trunk
  • thirst increase
  • urination increase

If you suspect an overdose, call this number to contact your poison control center: (800) 222-1222.

Periodic Tests[top]

Ask your doctor which of these tests should be done periodically while you are taking this drug:

  • adrenal function test
  • eye, ear, nose, and throat exam

last reviewed February 28, 2021