Search results below include Worst Pills, Best Pills Newsletter Articles where your
selected drug is a secondary subject of discussion.
October 2025
Approved by the Food and Drug Administration in 2012, linaclotide (LINZESS) is an expensive drug for constipation and for symptoms of irritable bowel syndrome with constipation. Based on our review, we have designated linaclotide as a Do Not Use drug because the randomized placebo-controlled trials supporting its approval demonstrated that its limited benefit (symptomatic relief of constipation in about one of five users) is offset by its diarrhea adverse effects (also reported by about one of five users).
June 2011
This article lists 355 drugs with names that are often confused with similar-sounding drug names. Find out what you can do to prevent getting the wrong drug.
June 2009
Do not use lubiprostone. There are safer and equally or more effective treatments for both chronic constipation and for the constipation variety of irritable bowel syndrome.
We have just asked the FDA to place a black box warning on this drug because it may cause abortions in women using it who are pregnant.
April 2007
The long-term safety of lubiprostone is unknown. Because lubiprostone is the first in a new class of drugs that works in a new way, it is possible that unknown and unpredictable side effects may occur after the drug is used in large numbers of patients.
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