Worst Pills, Best Pills

An expert, independent second opinion on more than 1,800 prescription drugs, over-the-counter medications, and supplements

spironolactone (ALDACTONE, CAROSPIR)


DRUG AND DIETARY SUPPLEMENT PROFILES

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
Search results below include Drug and Dietary Supplement Profiles where your selected drug is a secondary subject of discussion.

drospirenone and ethinyl estradiol (GIANVI, MELAMISA, NIKKI, YASMIN, YAZ, ZARAH)
  • We list this drug as a Do Not Use drug because it can cause increased blood levels of potassium and is no more effective than other oral contraceptives in preventing pregnancy.

WORST PILLS, BEST PILLS NEWSLETTER ARTICLES

Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a secondary subject of discussion.

No Proven Advantage for the New Combined Birth Control Pill Drospirenone and Estetrol (NEXTSTELLIS)
July 2023
A 28-day, fixed-dose, combined oral contraceptive marketed as NEXTSTELLIS has no proven advantage over older, well-studied, combined oral contraceptives. Public Citizen’s Health Research Group has designated Nextstellis as a Do Not Use medication, consistent with our designation of other drospirenone-containing combined oral contraceptives.
Potassium: An Essential but Often Overlooked Nutrient
November 2021
Learn about the health benefits of consuming an adequate amount of dietary potassium. To help readers assess their potassium intake, we offer a list of potassium-rich foods.
Potassium Increases Due to Drug Interactions Can Be Dangerous
November 2008
One of the most common drug interactions occurs when patients take two or more drugs that can each increase blood potassium levels. The resulting condition, hyperkalemia (increased blood potassium levels), can cause nausea, fatigue, muscle weakness or tingling sensations, as well as heart abnormalities, showing up as an abnormal electrocardiogram. In some cases it can be fatal. The article lists 50 drugs which, especially when used in combination, can cause hyperkalemia.
BIDIL, a Heart Drug Targeted at African Americans, Stirs Complex Controversy
September 2005
You should only be using BiDil for congestive heart failure in combination with other drugs for this condition. For one-fourth of the cost, with the cooperation of your physician, you can get prescriptions for the two generically-available drugs that comprise BiDil, isosorbide dinitrate and hydralazine.
Cutting Your Drug Bill While Reducing Your Risk Of Avoidable Adverse Drug Reactions: Six Examples
February 2005
This article will look at the potential savings for the individual consumer if the alternative treatments recommended in Worst Pills, Best Pills were used for six DO NOT USE drugs. All six are listed in the Drug Topics Magazine Top 200 selling drugs in U.S. in 2003. The drugs are: celecoxib (CELEBREX) used for arthritis and pain; the Alzheimer’s disease drug donepezil (ARICEPT); drospirenone with ethinyl estradiol (YASMIN 28), an oral contraceptive; esomeprazole (NEXIUM) the “new purple pill” for heartburn; montelukast (SINGULAIR), a drug approved for both asthma and hay fever; and valdecoxib (BEXTRA), an arthritis drug very similar to celecoxib.The combined sales of these six DO NOT USE drugs was $8.1 billion with more that 75 million prescriptions dispensed in 2003.
DO NOT USE UNTIL 2011 Eplerenone (INSPRA) For High Blood Pressure
December 2003
This statement appears in the professional product labeling, or package insert, for eplerenone: “The principal risk of INSPRA is hyperkalemia. Hyperkalemia can cause serious, sometimes fatal, arrhythmias (heart rhythm disturbances).”
Oxybutynin Patches (OXYTROL): A Grossly Overpriced Product For Overactive Bladder
July 2003
You should check the list of drugs that can cause loss of bladder control before starting drug treatment for this condition. You may be able to change from a drug that causes loss of bladder control to a drug that does not or alter the dose. This may be enough to solve the problem.
Do Not Use! The New Birth Control Pill Drospirenone With Ethinyl Estradiol (YASMIN)
April 2002
The combination birth control pill of ethinyl estradiol with drospirenone (YASMIN) was approved by the Food and Drug Administration (FDA) in April 2001. Combination birth control pills contain the hormones estrogen and progestin. There is no medical reason that you should be using Yasmin rather than one of the older pills containing the progestins norgestrel, levonorgestrel or norethindrone.