Worst Pills, Best Pills

An expert, independent second opinion on more than 1,800 prescription drugs, over-the-counter medications, and supplements



A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
Search results below include Drug and Dietary Supplement Profiles where your selected drug is a secondary subject of discussion.

mirabegron (MYRBETRIQ)
  • We list this drug as Do Not Use because the drug’s significant risks far outweigh its minimal benefits for treatment of overactive bladder.


Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a secondary subject of discussion.

Lifestyle Changes Helpful for Men With Urinary Symptoms, Clinical Trial Shows
July 2024
Almost one-third of older men experience lower urinary tract symptoms, such as hesitancy or slow urinary stream, dribbling or incomplete emptying of the bladder, urinary urgency or need to urinate many times during the day or at night. Learn about a recent clinical trial, published in the BMJ, that found that use of standardized assessments and lifestyle advice for men in the primary-care setting led to sustained reductions in urinary symptoms compared to usual care.
False-Hope Alzheimer’s Disease Drugs
October 2018
The FDA has approved four drugs for treating Alzheimer’s disease, a devastating brain disorder that affects nearly 6 million Americans, most of whom are elderly. Learn why we have designated each of these drugs as Do Not Use.
Do Not Use Mirabegron (MYRBETRIQ) for Overactive Bladder
January 2018
Overactive bladder is a bothersome — but not serious — medical problem that becomes more common with age. Find out why mirabegron is the wrong choice for treating this condition.
Saw Palmetto Extract: Ineffective for Enlarged Prostate Symptoms
December 2011
Read about the results of a study comparing higher doses of saw palmetto extract with a placebo for treating some common symptoms of benign prostate enlargement (such as urinary retention and incomplete emptying of the bladder).
Drug Mix-Ups
June 2011
This article lists 355 drugs with names that are often confused with similar-sounding drug names. Find out what you can do to prevent getting the wrong drug.
29 Medications That May Cause Adverse Interactions with Thyroid Drugs
September 2008
Thyroid medications are among the most widely-prescribed drugs in the U.S. In this article, we review 29 different medications that can have harmful interactions with thyroid medicines such as levothyroxine (Synthroid). There are four major kinds of interaction problems that can occur: • Certain medications can decrease the absorption of levothyroxine resulting in lower levels in the blood. • Other medications can increase the rate at which the body gets rid of levothyroxine, also resulting in lower thyroid levels in the blood. • Other medications can cause changes of levothyroxine binding in blood, decreasing the body's ability to use levothyroxine. • Levothyroxine can affect the safety or effectiveness of other medications by raising or lowering the levels of these other drugs in the blood, causing them to be either infective (lower levels) or dangerous (higher levels).
A Review of Solifenacin (VESICARE) and Darifenacin (ENABLEX) for Overactive Bladder
May 2005
Both solifenacin or darifenacin are only modestly effective compared to a placebo, both carry the risk of significant harm to older adults, and both are overpriced.
A Review of Trospium (SANCTURA) for Overactive Bladder
November 2004
Trospium appears to offer no advantage over long-acting anticholinergics for treatment of overactive bladder, and its poor absorption from the gastrointestinal tract could be problematic.
A Review of Two More Drugs For Erectile Dysfunction: Vardenafil (LEVITRA) And Tadalifil (CIALIS)
January 2004
You should wait at least seven years from the date of release to take any new drug unless it is one of those rare “breakthrough” drugs that offers you a documented therapeutic advantage over older proven drugs.
The Same Old Sad Story - Inappropriate Prescribing to the Elderly
February 2002
“Inappropriate medication use is a major patient safety concern, especially for the elderly population.” This is the first sentence of a study published in the December 12, 2001 issue of the Journal of the American Medical Association. The majority of the 33 drugs in this study have been on the market for years........