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May 2025
Patients who take the antipsychotic drug clozapine are at increased risk of neutropenia (low count of neutrophils, a type of white blood cell). Although the FDA is ending the Risk Evaluation and Mitigation Strategy program for clozapine, patients taking the drug should still have their absolute neutrophil counts monitored at the frequency stated in the drug’s prescribing information.
March 2025
Xanomeline-trospium (Cobenfy), a recently approved drug for schizophrenia, blocks different nervous system receptors than previous drugs. The clinical trials of xanomeline-trospium were only five weeks in duration and did not compare the drug to second-generation antipsychotic drugs. Public Citizen’s Health Research Group has classified the drug as Do Not Use for Seven Years.
February 2025
The FDA recently provided an update on marijuana (cannabis) use, including the clinical implications of the medical and recreational use of marijuana-related products. In 2024 the Drug Enforcement Administration proposed a rule that would move marijuana to Schedule III, a classification for drugs and other substances with an intermediate potential for physical or psychological dependence. There are two FDA-approved drugs derived from marijuana with narrow indications.
March 2023
A recently published study provided evidence that lithium treatment in persons with bipolar disorder may decrease the risk of osteoporosis.
April 2022
A new well-designed study conducted by U.K. researchers found that mirtazapine is not beneficial for treating agitated behaviors in dementia patients and is potentially linked to an increased risk of death.
February 2018
No other schizophrenia medicine is more dangerous than clozapine. Learn about the drug’s serious unique risks and why it should be used only by severely ill schizophrenia patients who have failed to respond adequately to other antipsychotic medications.
August 2011
Most prescriptions for antipsychotic drugs to people in nursing homes are inappropriate and quite dangerous. Find out what you can do to protect your family or friends.
June 2011
This article lists 355 drugs with names that are often confused with similar-sounding drug names. Find out what you can do to prevent getting the wrong drug.
March 2009
The article lists 57 different drugs that can cause dementia if used. This can be even more problematic if more than one of these drugs is being taken. These drugs are only one class of drugs that can cause mental deterioration and next month's issue will discuss additional drugs that can also impair thinking.
January 2008
More than 70 million prescriptions a year are filled for these popular antidepressants, including Prozac, Paxil, Zoloft, Luvox, Celexa and Lexapro. This article gives details about more than 60 other widely prescribed prescription drugs that can have harmful interactions if used with these antidepressants. The two different kinds of interactions are also discussed.
September 2003
Canadian drug regulatory authorities reviewed reported cases of serotonin syndrome in the July 2003 issue of the Canadian Adverse Reaction Newsletter. The serotonin syndrome is a potentially life-threatening adverse drug reaction involving an excess of serotonin, a naturally occurring nerve transmitter.
July 2003
You should check the list of drugs that can cause loss of bladder control before starting drug treatment for this condition. You may be able to change from a drug that causes loss of bladder control to a drug that does not or alter the dose. This may be enough to solve the problem.
June 2003
The manufacturer of the antipsychotic drug risperidone (RISPERDAL), announced on April 16, 2003, that an important new warning had been added to the professional product labeling, or package insert, for the drug concerning cerebrovascular adverse effects, including stroke and transient ischemic attack (temporary reduction of blood flow to the head), when the drug is used to treat elderly patients for dementia. In some of these cases the result was death.
June 2003
You should follow the Health Research Group’s Seven Year Rule with aripiprazole. There is no evidence to suggest that aripiprazole is a “breakthrough” drug.