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October 2026
Learn about vitamin B6 and the health risks of long-term use of high-dose vitamin B6 supplements. It is best to consume all vitamins, including vitamin B6, from dietary sources and to avoid taking supplements that contain megadoses of vitamin B6.
October 2019
Next to Parkinson’s disease, drug-induced parkinsonism is the second most common cause of parkinsonism, accounting for about 8-12% of all parkinsonism cases. Find out which commonly used drugs can cause this condition.
February 2013
MIRAPEX (pramipexole) is a drug frequently used for restless leg syndrome, for which there are other safer, effective nondrug treatments, as discussed in the article. It also is used for Parkinson's disease. A recent review has found that this drug can increase the risk of heart failure. Find out how to recognize early symptoms of heart failure.
June 2007
On March 29, 2007, the Parkinson’s disease drug pergolide (PERMAX) was withdrawn from the market. This follows the publication of two studies which show an increased risk of heart valve damage in patients taking pergolide compared to those not taking the drug. You should contact your health care professional immediately if you are taking pergolide to discuss other treatments. Do not discontinue taking pergolide abruptly. The dosage of the drug must be gradually decreased.
September 2003
Canadian drug regulatory authorities reviewed reported cases of serotonin syndrome in the July 2003 issue of the Canadian Adverse Reaction Newsletter. The serotonin syndrome is a potentially life-threatening adverse drug reaction involving an excess of serotonin, a naturally occurring nerve transmitter.