Worst Pills, Best Pills

An expert, independent second opinion on more than 1,800 prescription drugs, over-the-counter medications, and supplements

sildenafil [erectile dysfunction] (VIAGRA)


Search results below include Disease and Drug Family Information where your selected drug is a primary subject of discussion.

Erectile Dysfunction
A number of drugs can cause sexual dysfunction in both women and men. Determining the potential benefits of vardenafil, tadalafil, or sildenafil is much more complex than for drugs that are used to treat cancer, heart disease, or high blood pressure, for example, where one of the potential benefits may be increased survival or avoidance of a heart attack or stroke. It is unlikely that untreated ED contributes to decreased survival, even though it may contribute to emotional distress and strained relationships.


A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
Search results below include Drug and Dietary Supplement Profiles where your selected drug is a primary subject of discussion.


Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a primary subject of discussion.

Erectile Dysfunction Drugs Increase Risk of Rare, Serious Adverse Ocular Events
December 2022
Recently published research provides the strongest evidence to date that erectile dysfunction drugs increase the risk of rare, serious adverse ocular events that can lead to vision loss.
“Male-Enhancing” Dietary Supplements Were Tainted With Dangerous Drugs
October 2020
In his editor’s column, Dr. Michael Carome discusses a recent report published in Morbidity and Mortality Weekly Reports that hammers home the potentially life-threatening dangers of using these illegal dietary supplements.
Commonly Used Oral Drugs That Can Cause Eye Problems; First of a Two-Part Series
December 2019
In this first of a two-part series, we review some of the many commonly prescribed medications that can damage your eyes and the steps that you can take to protect yourself from these adverse effects. The second part in this series will appear in our February 2020 issue.
Medications That Cause Hearing Problems
November 2019
For most people with hearing loss, the condition likely is age-related or due to long-term exposure to loud noise. But for some patients, the cause of the problem can be found in the medicine cabinet.
Potentially Dangerous Interactions Between Erectile Dysfunction Drugs and Other Medications
July 2019
Find out about the many prescription medications that can interact in dangerous ways with the four drugs approved by the FDA for treating erectile dysfunction in men.
Taking These Medications With Grapefruit Can Be Dangerous!
June 2019
Read about the many prescription drugs that can interact in dangerous ways with grapefruit or grapefruit products.
Big Pharma Rings in New Year with More Price Gouging
March 2018
In his editor’s column, Dr. Michael Carome highlights the most recent wave of price hikes by major pharmaceutical companies at the start of 2018.
Drugs That Cause Hearing Problems
November 2015
For most people with hearing loss, the condition likely is age-related or due to long-term exposure to loud noise. But for some patients, the cause of the problem can be found in the medicine cabinet. Learn about some commonly used medications that can cause hearing disorders.
Update on Grapefruit Juice-Drug Interactions
July 2012
This article updates and expands our earlier list of drugs that can have harmful interactions with grapefruit juice. The list now includes 82 different drugs.
Erectile Dysfunction Drugs and Hearing Loss
December 2010
The article describes evidence that sudden hearing loss can occur in people using certain erectile dysfunction drugs, and tells you which drugs can cause this problem. It also describes other symptoms that can accompany the onset of this drug-induced hearing loss.
Alpha-Blockers for Prostate Enlargement: Some Important Drug Interactions
June 2009
Taking alpha-blockers in combination with drugs for erectile dysfunction and with other drugs can cause dizziness and fainting. In this article we will discuss alfuzosin (UROXATRAL), doxazosin (CARDURA), tamsulosin (FLOMAX) and terazosin (HYTRIN) and drugs with which they can have harmful interactions.
Watch out for Interactions Between Drugs for Erectile Dysfunction and Other Medications
January 2009
The article lists 56 drugs that can interact with the three drugs for erectile dysfunction (ED): sildenafil (VIAGRA), tadalafil (CIALIS) and vardenafil (LEVITRA). Eight of the drugs are either nitrates such as nitroglycerin or a certain group of high blood pressure drugs.In combination with ED drugs, these drugs can cause a dangerous fall in blood pressure that could lead to a heart attack or stroke. Thirty-two other drugs can inhibit the enzyme that helps the body to eliminate the ED drugs, resulting in abnormally high blood levels of the drugs and a potentially harmful "overdose" even though you are actually taking the recommended amount. The other 16 drugs speed up the metabolism of the ED drugs, thereby lowering the blood levels and reducing the effectiveness of the ED drugs.
Drug-Induced Eye Toxicity: 62 Drugs That Can Cause Eye Disease
April 2008
This article, based on a recent review in Drug Safety, lists 62 prescription drugs that can cause eye disease. The range of drug-induced eye diseases includes diseases of the eyelids, glaucoma, cataracts, retinal damage and optic nerve damage. As is true for drug-induced diseases in other parts of the body, you should consider newly developed eye symptoms beginning shortly after starting a new medication to be possibly drug-induced and consult a physician.
“Reminder” Ads: Innuendo Minus Information
November 2007
At present, facing increasing competition and dwindling sales, Pfizer has launched a “reminder” ad for Viagra that skirts FDA requirements. Because any ad that mentions the product’s name and the condition that it treats must also disclose its side effects, Pfizer has eclipsed its message with a song and an image. The song is “Viva Viagra” (to the tune of “Viva Las Vegas”) and the image is that of a jam session of guitar-playing 40-something-year-old men singing about their “not straying” and their devotion to an unseen “she.” The ad omits a caution against sexually transmitted diseases (STDs) and HIV, although this is flashed briefly on the screen. The result is an undermining of the pharmaceutical manufacturers’ original rationale for direct-to-consumer advertising: that it would be a tool to provide important information to patients who would benefit from the knowledge.
Manipulating the Hispanic Market: The Case of Viagra
September 2007
This article describes Pfizer's attempts to promote Viagra for erectile dysfunction by targeting Latinos, in part through support to a Latino physicians association.
Internet-Sold Dietary Supplements For Erectile Dysfunction May Endanger Users
October 2006
The FDA analysis found that some of these products illegally contained sildenafil (VIAGRA), which is FDA-approved for erectile dysfunction. Others contained chemicals similar to sildenafil.
Erectile Dysfunction Drugs Can Cause Vision Loss
January 2006
We have asked the Food and Drug Administration (FDA) to add black box warnings to the professional product labels, or package inserts, for the erectile dysfunction drugs sildenafil (VIAGRA), tadalafil (CIALIS), and vardenafil (LEVITRA). The warnings would alert prescribers to the possibility of irreversible vision loss with the use of these drugs.
The Dark Side of Viagra: Erectile Dysfunction Drugs And Vision Problems
August 2005
You should not use sildenafil Viagra), vardenafil(Levitra), or tadalafil(Cialis) for recreational purposes because there is no medical benefit to be gained. The possible harm from these drugs, no matter how small, will always outweigh a lack of medical benefit. If you experience any visual problems while using these drugs, notify your doctor immediately.
Grapefruit Juice and Prescription Drugs: Some Dangerous Interactions
February 2004
The January 5th issue of the Medical Letter, a widely respected source of independent information about pharmaceuticals and dietary supplements, has a review of the increasingly researched problem of the interaction between grapefruit juice and many prescription and over-the-counter drugs. Like most interactions between chemicals in the body, this one involves the impairment, by grapefruit juice, of the body’s ability to metabolize many drugs, leading to higher than expected — and sometimes dangerous — levels of these drugs.This article lists the drugs.
Drug Induced Psychiatric Symptoms (Part 2)
November 2002
This is the second of a two-part series on drug-induced psychiatric symptoms that began in last month’s Worst Pills, Best Pills News. The information is based on the July 8, 2002 issue of The Medical Letter on Drugs and Therapeutics. Article lists drugs and adverse effects.


Search results below include Additional Information from Public Citizen where your selected drug is a primary subject of discussion.

Petition to the FDA to require a black box warning for erectile dysfunction drugs (Viagra, Cialis, Levitra) to warn of the potential for irreversible vision loss (HRG Publication #1753)
Viagra accounts for more cases of a type of vision loss called ischemic optic neuropathy (ION) than any other drug (19 percent) and more than double the percentage of the next most often-reported drug.
Letter to the Medicines Control Agency, United Kingdom, urging them to require important warnings on labeling of sildenafil/Viagra. (HRG Publication #1454)
Public Citizen's Health Research Group is writing to urge the Medicines Control Agency to require important warnings on the labeling of the drug sildenafil (Viagra) that have been omitted from the drug's labeling in the United States.
Letter to the Therapeutic Products Program in Canada urging them to require important warnings on the labeling of sildenafil/Viagra. (HRG Publication #1452)
Public Citizen has petitioned the United States Food and Drug Administration (FDA) on July 1, 1998 and again on August 20, 1998 to correct the dangerously deficient labeling of sildenafil in the U.S. These two petitions are attached for your reference.
Letter to the Food and Drug Administration urging them to immediately convene an advisory committee to review various serious problems related to the use of sildenafil/Viagra. (HRG Publication #1451)
One purpose of this letter is to demand that the FDA immediately convene a meeting on Viagra of its cardiovascular advisory committee--a committee which was completely bypassed during the dangerously-rushed six months between the submission of the new drug application for Viagra to the FDA and its approval.
Petition to the Food and Drug Administration to change the labeling and other sources of information on sildenafil/Viagra to reflect problems with the drug. (HRG Publication #1445)
The purposes of this letter are to petition FDA to change the labeling and other sources of information about Viagra to add important information about the drug's dangers currently missing from such sources and to warn doctors and patients that a substantial proportion of patients using the drug are unwittingly using it to treat impotence or other types of sexual dysfunction which are probably adverse reactions caused or worsened by other drugs known to impair sexual function.