Worst Pills, Best Pills

An expert, independent second opinion on more than 1,800 prescription drugs, over-the-counter medications, and supplements

propoxyphene (DARVON, DARVON-N)


Search results below include E-Alerts where your selected drug is a primary subject of discussion.


Search results below include Disease and Drug Family Information where your selected drug is a primary subject of discussion.

Most of the time when someone is able to swallow, they should first try a non-opioid drug such as aspirin taken by mouth. If aspirin alone is not effective, it can be combined with an opioid, such as codeine. These two drugs work in different ways, and when they are used together, they generally relieve pain that would otherwise require a higher dose of an opioid, while causing fewer adverse effects.


A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
Search results below include Drug and Dietary Supplement Profiles where your selected drug is a primary subject of discussion.


Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a primary subject of discussion.

Inappropriate Prescribing of Medicines in the Elderly: A Persistent Problem
March 2013
Approximately 20 percent of prescriptions for elderly patients in primary care settings are inappropriate, leading to adverse reactions that are entirely preventable. The article lists some of the most common inappropriately prescribed drugs.
Delayed FDA Removal of Painkiller Propoxyphene (DARVON, DARVOCET) From U.S. Market Has Cost More Than 1,000 U.S. Lives
January 2011
Learn about our efforts to ban Darvon and our warnings about the drug going back 32 years. Why did the FDA take so long to ban it compared to the United Kingdom and Europe?
Dextromethorphan (DELSYM, ROBITUSSIN DM) for Cough: More Reasons to Avoid It
June 2010
Find out why you should not use cough products such as ROBITUSSIN DM that contain dextromethorphan. Also view a list of 22 other drugs that can have harmful interactions with dextromethorphan.
Aripiprazole (ABILIFY) Drug Interactions
April 2010
The article lists 53 drugs that can interact with the psychiatric drug ABILIFY to either increase the amount in the body, which can lead to toxicity, or decrease the amount rendering the drug less effective.
Painkiller DARVOCET Now Phased Out of U.K. Market; Still Widely Prescribed in the U.S.
January 2008
Why is this big-selling, extremely dangerous, not very effective narcotic painkiller still on the market in the U.S. despite haveing been withdrawn in the U.K.? Learn about how it kills more than 200 people a year.
Health Research Group Petitions to Phase Out the Sale of the Painkiller Propoxyphene (DARVON, DARVOCET, and Generic Versions)
June 2006
On Feb. 28, 2006, the Health Research Group petitioned the Food and Drug Administration (FDA) to immediately begin phasing out the sale of the dangerous painkiller propoxyphene (DARVON). The reason for the petition is that propoxyphene has been associated with over 10,000 confirmed deaths and 2,110 reported accidental deaths in the U.S. from 1981 through 1999. There are many generic versions of propoxyphene on the market, as well as a number of products that combine propoxyphene with acetaminophen (TYLENOL). These products are sold as DARVOCET and are also widely sold as generic drugs. A phased withdrawal, instead of an immediate ban, is necessary because of the addicting properties of the drug and the need to switch patients to other painkillers.


Search results below include Additional Information from Public Citizen where your selected drug is a primary subject of discussion.

Letter to FDA Praising Food Safety Cautiousness, Attacking Drug Safety Recklessness (HRG Publication #1903)
In contrast to becoming more active and cautious in enhancing food safety by removing potentially dangerous products before they have caused harm, several FDA decisions in the past year regarding prescription drugs can only be described as reckless.
Petition Asking FDA to Reconsider Banning Propoxyphene (Darvon) (HRG Publication #1896)
This petition asks the FDA to reconsider granting our petition to ban Propoxyphene (Darvon)
FDA Committee Vote Confirms Darvon’s Risks Outweigh Benefits, Drug Should Be Banned
Today’s Food and Drug Administration (FDA) advisory committee vote confirms that the risks of propoxyphene (Darvon) outweigh its benefits. The FDA must, therefore, remove it from the market.
Testimony of Sidney Wolfe Before Food and Drug Administration Advisory Committee on Propoxyphene (DARVON) (HRG Publication #1856)
Dr. Wolfe testifies before the Food and Drug Administration and advocates for a two-year phased withdrawal of these products.
Petition to FDA to ban all propoxyphene (DARVON) products; prescription painkiller causes many fatalities (HRG Publication #1762)
Petition by Sidney M. Wolfe, M.D., Dan Suzman, Ulf Jonasson, Dr.PH and Birgitta Jonasson, Ph.D.