Worst Pills, Best Pills

An expert, independent second opinion on more than 1,800 prescription drugs, over-the-counter medications, and supplements

ofloxacin (FLOXIN)


E-ALERTS

Search results below include E-Alerts where your selected drug is a primary subject of discussion.


DISEASE AND DRUG FAMILY INFORMATION

Search results below include Disease and Drug Family Information where your selected drug is a primary subject of discussion.

Antibiotics
Antibiotics (drugs used to treat bacterial infections) are overwhelmingly misprescribed in the United States. Despite congressional hearings and numerous academic studies on this issue, it has become the general consensus that 40 to 60% of all antibiotics in this country are misprescribed. New studies continue to confirm the fact that a large proportion of antibiotic prescribing for both children and adults continues to be inappropriate.
Fluoroquinolones
One of the biggest-selling and most overprescribed classes of drugs in the United States is the family called fluoroquinolones. One clue that a drug your doctor wants to give you is in this class is the fact that the generic names of all such drugs approved in the United States include the sequence floxacin. These drugs have been alternatives for individuals allergic to, or with infections resistant to, other antibiotics. Some fluoroquinolones are commonly misprescribed for colds, sore throats, bladder infections, or community-acquired (as opposed to hospital-acquired) pneumonia.

DRUG AND DIETARY SUPPLEMENT PROFILES

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
Search results below include Drug and Dietary Supplement Profiles where your selected drug is a primary subject of discussion.


WORST PILLS, BEST PILLS NEWSLETTER ARTICLES

Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a primary subject of discussion.

Important Drug Interactions for the Anticoagulant Warfarin
August 2020
Patients taking the commonly used blood thinner warfarin (COUMADIN, JANTOVEN) should be aware that it has clinically important interactions with numerous other prescription and over-the-counter medications, as well as some dietary supplements.
Fluoroquinolone Antibiotics Can Increase the Risk of Aortic Rupture, FDA Warns
July 2019
Read about the growing body of evidence showing that the commonly prescribed fluoroquinolone antibiotics increase the risk of potentially fatal ruptures or tears of the aorta, the largest blood vessel in the body.
Medications that Cause Taste Disorders
April 2019
Drugs are the most frequent cause of taste disturbances. In this article, we identify more than 60 commonly used prescription medications that have been linked to problems with taste.
New Study Links Fluoroquinolones to Life-Threatening Blood Vessel Complication
September 2018
In this article, we discuss results of new research linking the widely overused fluoroquinolone antibiotics to an increased risk of life-threatening damage to the body’s largest blood vessel, the aorta.
FDA Requires Stronger Warnings for Commonly Used Antibiotics
February 2017
One of the biggest-selling but most overprescribed classes of antibiotics in the U.S. is the family called fluoroquinolones. Learn why the FDA required the addition of new black-box warnings to the labels of these antibiotics that describe risks of several disabling and potentially permanent side effects.
Drugs That Cause Sun-Related Skin Reactions
July 2016
Summer is a terrific time for healthy outdoor activities, such as walking, hiking, biking and swim¬ming. But for an unlucky few, certain medications can lead to adverse skin reactions following exposure to the sun. Find out whether you are at risk and how to protect yourself.
Fluoroquinolones Linked to Life-Threatening Blood Vessel Complications
April 2016
In this article, we discuss results of new research linking the widely overused fluoroquinolone antibiotics to an increased risk of life-threatening damage to the body’s largest blood vessel, the aorta.
Often-Misused Fluoroquinolone Antibiotics Pose Serious Risks
October 2015
Fluoroquinolones are the biggest-selling and most overprescribed classes of antibiotics in the U.S. Learn why Public Citizen's Health Research Group designates two of the five available fluoroquinolones as Do Not Use and why the other three should be used only in limited circumstances.
Smoke & Mirror Marketing (& Other Clever Big Pharma Tricks)
May 2010
The article reviews 12 prescription drugs, many of which are top-sellers, all of which are greatly overpriced in comparison to older "versions" of the same drugs. The patents on the old drugs expired so the "innovative" companies patented these new products, gaining a patent on them, and, for all practical purposes, using them as a license to print money. There is no evidence that any of the new ones are better than the now less-expensive, old versions.
Antacid Drug Interactions
October 2009
Antacids can interact with a number of medications, either increasing or decreasing drug effect.
Drug-induced Cognitive Impairment: Part 2: Delirium and Dementia
April 2009
This second article about drug-induced dementia or delirium lists and discusses an additional 79 drugs that can cause these reversible kinds of mental deterioration. The two articles collectively review 136 drugs that can cause these serious side effects, especially in older people.
Tizanidine: Watch Out for Drugs Interacting With This Muscle Relaxant
October 2008
Tizanidine (ZANAFLEX) is a muscle relaxant for which more than 3.8 million prescriptions were filled in the U.S. last year. The article lists more than 64 drugs with which it can have dangerous interactions resulting in excess sedation, difficulty breathing or dangerously low blood pressure that can result in falling.
29 Medications That May Cause Adverse Interactions with Thyroid Drugs
September 2008
Thyroid medications are among the most widely-prescribed drugs in the U.S. In this article, we review 29 different medications that can have harmful interactions with thyroid medicines such as levothyroxine (Synthroid). There are four major kinds of interaction problems that can occur: • Certain medications can decrease the absorption of levothyroxine resulting in lower levels in the blood. • Other medications can increase the rate at which the body gets rid of levothyroxine, also resulting in lower thyroid levels in the blood. • Other medications can cause changes of levothyroxine binding in blood, decreasing the body's ability to use levothyroxine. • Levothyroxine can affect the safety or effectiveness of other medications by raising or lowering the levels of these other drugs in the blood, causing them to be either infective (lower levels) or dangerous (higher levels).
Public Citizen Urges FDA to Warn Consumers About Risk of Tendon Rupture Associated With Certain Antibiotics
November 2006
You should stop taking fluoroquinolones(listed in the article) and immediately contact your physician if you experience pain in any tendon while taking one of these antibiotics so you can be switched to another antibiotic.
Fluoroquinolone Antibiotics Implicated in Life-Threatening Diarrhea
February 2006
Antibiotic-associated diarrhea (AAD) is quite common and its incidence varies from 5% to 20% of patients depending on which antibiotic they are taking. The article lists some of the drugs most associated with this potentially life-threatening adverse reaction.
Drug Induced Peripheral Neuropathy From The Fluroquinolone Antibiotics
December 2004
The Food and Drug Administration (FDA) now requires that the professional product labeling, or package inserts, for all fluroquinolone antibiotics must warn about the possibility of peripheral neuropathy (nerve damage). A list of the fluroquinolone antibiotics currently available in the U.S. appears at the end of this article.
Drug Interaction Reminder: Fluoroquinolone Antibiotics and the Anticoagulant (Blood Thinner) Warfarin (COUMADIN)
September 2004
You should consider that all fluoroquinolone antibiotics have the potential to interact with warfarin and your physician should be ordering blood tests to monitor the status of your blood clotting if one of these antibiotics is needed and you are using warfarin. This is the safest thing to do.
Drug-Induced Taste Disorders
September 2003
DO NOT stop taking any of the drugs listed in the table without first consulting your physician. You should report any alteration in your sense of taste to your physician if you are taking a drug.
Inappropriate Prescribing Of Fluoroquinolone Antibiotics, Ciprofloxacin (CIPRO), Gatifloxacin (TEQUIN), And Others
July 2003
In this study, the researchers evaluated 100 consecutive patients who went to the emergency room and received a prescription for a fluoroquinolone antibiotic. Of the 100 patients, 81 (81%) received a fluoroquinolone antibiotic for an inappropriate use. In 43 (53%) of these patients, a fluoroquinolone was found inappropriate because another antibiotic was considered first-line treatment, and in 27 (33%) patients there was no evidence of an infection and therefore no indication for the use of any antibiotic.
Selling New Drugs Using Smoke and Mirror (Images)
March 2003
You should avoid these "new" single mirror images of old drugs, not out of concern about their safety or effectiveness, but because they are the same as the old drugs. In the long run, they cause economic harm both to individuals and to the health care system because they have come on the market with extended monopoly protection. Article lists some examples.

ADDITIONAL INFORMATION FROM PUBLIC CITIZEN

Search results below include Additional Information from Public Citizen where your selected drug is a primary subject of discussion.

Testimony Before the FDA’s Antimicrobial Drugs and Drug Safety and Risk Management Advisory Committees Regarding Fluoroquinolone Antibiotics (HRG Publication #2282)
Public Citizen is concerned about the significant overprescribing of fluoroquinolones. We recommend that the Food and Drug Administration (FDA) require the addition of black-box warnings to the labels of all such antibiotics about the risk of life-threatening abnormal heart rhythms.
FDA Must Do More to Warn Patients Taking Flouroquinolone Antibiotics of Possible Tendon Ruptures
Statement of Sidney Wolfe, M.D., Director of the Health Research Group at Public Citizen
Antibiotic Leads to Tendon Ruptures; FDA Ignores Risks
Despite long-standing evidence that fluoroquinolone antibiotics can cause tendon ruptures, the Food and Drug Administration (FDA) has failed to increase its warnings to patients and physicians about the dangers of the medicines, Public Citizen told a federal court Thursday.
Public Citizen Petitions the FDA to Include a Black Box Warning on Fluoroquinolone Antibiotics (HRG Publication #1781)
Public Citizen, representing more than 100,000 consumers nationwide, hereby petitions the Food and Drug Administration (FDA), pursuant to the Federal Food, Drug and Cosmetic Act 21 U.S.C. Section 355(e)(3), and 21 C.F.R. 10.30, to immediately add a black box warning regarding the risks of tendinopathy and tendon rupture to the product labels of all fluoroquinolone antibiotics presently on the market in the United States.
Petition to Require a Warning on All Fluoroquinolone Antibiotics (HRG Publication #1399)
Based on more than 130 reports of tendon inflammation (many involving rupture), most frequently involving the Achilles tendon, in persons using the widely-prescribed class of antibiotics known as fluoroquinolones, Public Citizen, representing consumers nationwide, hereby petitions the F.D.A. to add a warning about this serous problem to the label of all fluoroquinolone antibiotics marketed in the United States. These include: