Worst Pills, Best Pills

An expert, independent second opinion on more than 1,800 prescription drugs, over-the-counter medications, and supplements

nefazodone (SERZONE)


E-ALERTS

Search results below include E-Alerts where your selected drug is a primary subject of discussion.


DISEASE AND DRUG FAMILY INFORMATION

Search results below include Disease and Drug Family Information where your selected drug is a primary subject of discussion.

Depression: When are Drugs Called For And Which Ones Should You Use?
Ironically, one of the kinds of depression that should not be treated with drugs is depression caused by other kinds of drugs. If someone is depressed and the depression started after beginning a new drug, it may well be drug-caused. Commonly used drugs known to cause depression include the following:

DRUG AND DIETARY SUPPLEMENT PROFILES

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
Search results below include Drug and Dietary Supplement Profiles where your selected drug is a primary subject of discussion.

nefazodone (SERZONE)
  • We list this drug as a Do Not Use drug because it causes liver failure.

WORST PILLS, BEST PILLS NEWSLETTER ARTICLES

Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a primary subject of discussion.

Important Drug Interactions for the Hypertension and Angina Drug Nifedipine
August 2021
Patients taking the widely prescribed calcium channel blocker nifedipine (PROCARDIA, PROCARDIA XL) should be aware that it has clinically important interactions with many other prescription medications.
Important Drug Interactions for Cholesterol-Lowering Drug Atorvastatin (LIPITOR)
April 2021
Patients taking the commonly prescribed drug atorvastatin, which is a member of the statin family of cholesterol-lowering drugs, should be aware that it has clinically important interactions with many other prescription medications.
Important Drug Interactions for Cholesterol-Lowering Drug Simvastatin
June 2020
Patients taking the commonly prescribed cholesterol-lowering drug simvastatin (FLOLIPID, VYTORIN, ZOCOR) should be aware that it has clinically important interactions with many other prescription medications.
Potentially Dangerous Interactions Between Erectile Dysfunction Drugs and Other Medications
July 2019
Find out about the many prescription medications that can interact in dangerous ways with the four drugs approved by the FDA for treating erectile dysfunction in men.
Colchicine Interactions with Other Drugs Can Be Life-Threatening
May 2019
Read about the many prescription medications that can interact in dangerous ways with colchicine, a commonly used drug for treatment of acute gout attacks.
Potentially Dangerous Digoxin Drug Interactions
November 2018
Read about the numerous medications that can interact with digoxin, a drug commonly prescribed for heart failure and atrial fibrillation. These interactions can result in either digoxin toxicity or decreased digoxin effectiveness depending on the other drug being used concomitantly.
Aripiprazole (ABILIFY) Drug Interactions
September 2018
Read about the more than two dozen medications that can have clinically important interactions with aripiprazole, one of the widely used newer atypical antipsychotic drugs that is approved by the FDA for treatment of several disorders including schizophrenia, bipolar disorder and depression.
How Effective Are Antidepressants for Depression?
February 2014
Some degrees of depression are less likely to respond to treatment with an antidepressant. This article reviews the evidence and evaluates 27 different antidepressants, labeling many as Do Not Use or Limited Use.
Update on Grapefruit Juice-Drug Interactions
July 2012
This article updates and expands our earlier list of drugs that can have harmful interactions with grapefruit juice. The list now includes 82 different drugs.
Serotonin Syndrome Due to Drug Interactions
April 2008
The article lists more than 30 prescription drugs that can cause the serotonin syndrome.
FDA: All Antidepressants Should Carry Warnings About Risks of Suicidal Thoughts in Young Adults
July 2007
Because of new information about increased risks of suicidal thoughts associated with the use of a variety of antidepressants, people of all ages should be monitored closely with all antidepressants after the drugs are first prescribed, switched or when the dosage is changed. Do not stop using any antidepressants without first consulting the prescriber.
Black Box Warning To Be Required On All Antidepressants Concerning Suicide Risk In Children And Adolescents
December 2004
Belatedly, the Food and Drug Administration (FDA) announced on October 15, 2004 that it is taking steps to inform parents and physicians about the risks of antidepressants when these drugs are used to treat major depressive disorder in children and adolescents.
Suicide Risk Added To The Professional Product Labeling For Eight Antidepressants
August 2004
At the request of the Food and Drug Administration (FDA), eight out of ten manufacturers of newer antidepressants have agreed to add a warning about the possibility of an increased risk of suicide associated with the use of these drugs. The warning will appear in the professional product labeling, or package insert, for these drugs.(listed in the article)
CBS Evening News on Serzone: New Concerns Over Anti-Depressant
June 2004
On April 15th of this year, the CBS Evening News asked Dr. Sidney Wolfe of Public Citizen "Is there any legitimate reason this drug should still be sold in the U.S. when it’s been taken off the market in other places for the same dangers?" Dr. Wolfe replied, "From a financial perspective, the only reason is to make money for Bristol Myers Squibb. But from a health perspective there is no justification for this drug being on the market."
Dangerous Antidepressant Nefazodone (SERZONE) Now Withdrawn From the Market in Europe, Canada, Australia and New Zealand
June 2004
In March, 2003 Public Citizen’s Health Research Group first petitioned the FDA to ban this uniquely dangerous antidepressant because of liver toxicity (see Worst Pills, Best Pills News March 2003).  As the toll of liver damage and death continued to rise, we amended our petition (see Worst Pills, Best  Pills News December 2003) and in March of this year we filed a lawsuit in U.S. District Court for the District of Columbia against the FDA because they had failed to act on our petition.
The Antidepressant Fluoxetine (Prozac) and Suicidal Ideation — Déjà vu 1991
May 2004
Fourteen years ago, in May 1991, the Health Research Group petitioned the Food and Drug Administration (FDA) to require a warning in the professional product labeling, or package insert, of fluoxetine (PROZAC) concerning the risk of suicidal impulses in patients using the drug. Fluoxetine belongs to the family of antidepressants known as selective serotonin re-uptake inhibitors, or SSRIs. Read the warning we asked for back then.
Updates: Rosuvastatin (CRESTOR) and Nefazodone (SERZONE)
April 2004
This article discusses why there is no medical reason that you or a family member should be taking either rosuvastatin or the anti-depressant nefazodone.
FDA Issues Public Health Advisory On Antidepressants And Suicide Risk In Children
December 2003
The Food and Drug Administration (FDA) issued a Public Health Advisory on October 27, 2003 about reports of suicidal thinking and suicide attempts in clinical trials of eight drugs in pediatric patients with major depressive disorder (MDD).
DO NOT USE! Dangerous Antidepressant Nefazodone (SERZONE) Withdrawn From The Market In Canada HRG Files Second Petition to Ban Nefazadone
December 2003
Nefazodone (SERZONE), a dangerous antidepressant long linked to liver toxicity and deaths, was withdrawn from the Canadian market effective November 27, 2003. The drug is produced by Bristol-Myers Squibb in both Canada and the U.S.
Important Safety Alert! Antidepressant Nefazodone (SERZONE) Withdrawn From the Market In All European Countries
March 2003
Bristol-Myers Squibb of Princeton, NJ announced on January 8, 2003 that it will pull the antidepressant nefazodone (SERZONE) in all European countries where it is marketed. The drug was withdrawn from the Swedish market in early 2002 and from Denmark in December 2002 after concerns about liver toxicity. If you or a family member are currently taking nefazodone, discuss with the prescribing physician switching to one of the numerous other, safer antidepressant drugs now on the market.
Drug Induced Psychiatric Symptoms (Part 2)
November 2002
This is the second of a two-part series on drug-induced psychiatric symptoms that began in last month’s Worst Pills, Best Pills News. The information is based on the July 8, 2002 issue of The Medical Letter on Drugs and Therapeutics. Article lists drugs and adverse effects.
Grapefruit Juice and Drug Interactions
June 2002
Grapefruit juice can interact with a number of therapeutically important drugs that could lead to the possibility of toxicity. These drugs are listed in the article.
Do Not Use! Life-threatening Liver Toxicity with the Antidepressant Nefazadone (SERZONE)
February 2002
The Food and Drug Administration (FDA) informed pharmaceutical giant Bristol-Myers Squibb Co. on December 10, 2001 that it must add a black box warning to the professional product label, or “package insert,” for the antidepressant nefazodone (SERZONE), informing doctors and pharmacists that life-threatening liver damage can occur with this drug.

ADDITIONAL INFORMATION FROM PUBLIC CITIZEN

Search results below include Additional Information from Public Citizen where your selected drug is a primary subject of discussion.

Supplement to Petition to the FDA to ban the anitidepressant drug nefazadone (SERZONE) (HRG Publication #1681)
We have now updated that analysis to cover the subsequent time period, April 1, 2002 through May 12, 2003. During that period, FDA adverse event data recorded an additional 9 deaths, for a total of 20 reports of death due to liver failure in people using Serzone.
Petition to the FDA to Ban the Antidepressant Drug Nefazadone (SERZONE) (HRG Publication #1657)
Our own analysis, based on adverse reaction reports to the FDA, revealed that, from 1994, when first marketed, through the first quarter of 2002, nefazodone was associated with at least 53 cases of liver injury including 21 cases of liver failure from which 11 people died.