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An expert, independent second opinion on more than 1,800 prescription drugs, over-the-counter medications, and supplements

diclofenac [oral] (CAMBIA, CATAFLAM, VOLTAREN, ZIPSOR, ZORVOLEX)


DISEASE AND DRUG FAMILY INFORMATION

Search results below include Disease and Drug Family Information where your selected drug is a primary subject of discussion.

Salicylates and Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
The salicylates are used to relieve pain and to reduce fever and inflammation. Aspirin, a nonsteroidal anti-inflammatory drug (NSAID), is the most well-known and frequently used salicylate. Other salicylates discussed on this web site are salsalate and choline and magnesium salicylates.

DRUG AND DIETARY SUPPLEMENT PROFILES

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
Search results below include Drug and Dietary Supplement Profiles where your selected drug is a primary subject of discussion.


WORST PILLS, BEST PILLS NEWSLETTER ARTICLES

Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a primary subject of discussion.

Important Drug Interactions for the Antifungal Drug Voriconazole
May 2023
Patients taking the antifungal drug voriconazole (VFEND), which is marketed in both oral and injectable forms, should be aware that it has clinically important interactions with many other prescription medications.
Important Drug Interactions for the Potassium-Sparing Diuretic Spironolactone
November 2022
Patients taking the commonly prescribed diuretic spironolactone should be aware that it has clinically important interactions with many other commonly used prescription and over-the-counter medications.
Important Drug Interactions for NSAIDs
May 2022
Patients taking any of the widely used nonsteroidal anti-inflammatory drugs (NSAIDs) should be aware that they all have clinically important interactions with many other medications.
NSAIDs Better Than Opioids for Pain Control Following Hospitalization or Minor Surgery
April 2022
Recently published research strongly suggests that treatment of acute pain after hospitalization or after outpatient dental surgery is best achieved with nonsteroidal anti-inflammatory drugs (NSAIDs) rather than opioids.
Important Drug Interactions for Angiotensin Receptor Blockers
March 2022
Patients taking any of the widely prescribed angiotensin receptor blockers used to treat hypertension, among other disorders, should be aware that they have clinically important interactions with many other commonly used prescription and over-the-counter medications.
Drug-Induced Hair Loss
October 2021
Learn about some of the commonly used medications that may lead to hair loss, also known as alopecia.
Medications That Cause Gastrointestinal Bleeding
September 2021
Gastrointestinal bleeding is a common cause of hospitalization and in severe cases can result in death. Find out which commonly used medications can cause gastrointestinal bleeding.
FDA Warns Against Using NSAIDs in Pregnancy at 20 Weeks or Later
March 2021
Learn why the FDA in October 2020 warned that pregnant women in general should avoid using nonsteroidal anti-inflammatory drugs (NSAIDs) at about 20 weeks or later in pregnancy because of the rare risks of pregnancy complications and serious harm to an unborn baby.
Important Drug Interactions for Angiotensin-Converting Enzyme Inhibitors
January 2021
Patients taking the widely prescribed angiotensin-converting enzyme (ACE) inhibitors, such as benazepril (LOTENSIN) and lisinopril (PRINIVIL, QBRELIS, ZESTRIL), should be aware that these medications have clinically important interactions with many other prescription and over-the-counter medications.
Important Drug Interactions for the Anticoagulant Warfarin
August 2020
Patients taking the commonly used blood thinner warfarin (COUMADIN, JANTOVEN) should be aware that it has clinically important interactions with numerous other prescription and over-the-counter medications, as well as some dietary supplements.
Drug-Induced Liver Injury
May 2020
There are more than 1,000 prescription and over-the-counter medications, as well as certain herbal and dietary supplements, that are implicated in liver injury, and the list continues to grow.
Important Drug Interactions for Immune-Suppressing and Cancer Drug Methotrexate
January 2020
Patients taking the commonly prescribed drug methotrexate, which is used to treat certain autoimmune diseases and several types of cancer, should be aware that it has clinically important interactions with many other prescription and over-the-counter medications.
Study Reveals Increased Risk of Bleeding, Stroke from Combined Use of Oral Blood Thinners and NSAIDs
March 2019
Millions of Americans take anticoagulants on a long-term basis to prevent the formation of potentially harmful clots. Learn why such patients should avoid using nonsteroidal anti-inflammatory drugs.
New Study Supports Link Between Oral Pain Reliever Diclofenac and Cardiovascular Risks
February 2019
This article discusses new research linking use of oral diclofenac, a nonsteroidal anti-inflammatory drug, to an increased risk of heart attacks, strokes and other adverse cardiovascular events.
Important Clopidogrel (PLAVIX) Drug Interactions
January 2019
Read about the many prescription and over-the-counter medications that can interact in dangerous ways with clopidogrel, a widely used anti-platelet drug.
Potentially Dangerous Digoxin Drug Interactions
November 2018
Read about the numerous medications that can interact with digoxin, a drug commonly prescribed for heart failure and atrial fibrillation. These interactions can result in either digoxin toxicity or decreased digoxin effectiveness depending on the other drug being used concomitantly.
Drug-Induced Hair Loss
July 2016
For most people with hair loss, the condition usually is age-related or due to the genes they inherited from their parents. But for some patients, the cause of the problem can be found in the medicine cabinet. Learn about some commonly used medications that can cause hair loss.
Further Evidence That CELEBREX Is a Do Not Use Drug; New Designation of Diclofenac (VOLTAREN) as a Do Not Use Drug; and Other Do Not Use NSAIDS
June 2014
Learn about new research that provides further evidence affirming our designation of celecoxib (CE¬LEBREX) as a Do Not Use drug and that has prompted us to reclassify diclofenac (VOLTAREN) from Limited Use to Do Not Use. Also find out which NSAIDs are least likely to cause adverse cardiovascular events, such as heart attacks and strokes.
Hypertension Drugs Plus NSAIDs May Injure Kidneys
April 2013
Recent evidence points to increased acute kidney injury associated with combining nonsteroidal anti-inflammatory drugs (NSAIDs) with two antihypertensive drugs: a diuretic plus either an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB). Find out the names of these drugs. This is especially important for patients with hypertension, diabetes, congestive heart failure or chronic kidney disease, because such patients are routinely treated with diuretics, ACE inhibitors and ARBs.
Interactions Between Methotrexate (TREXALL) and Proton Pump Inhibitors (PPIs) and Many Other Drugs
January 2011
This article discusses the dangerous interactions that can occur when using methotrexate (TREXALL) with certain other drugs. See our list of 27 drugs you should never take with methotrexate.
Liver Toxicity With Topical Diclofenac Sodium (VOLTAREN)
March 2010
Although skin application of drugs usually results in lower blood levels than oral use, cases of liver toxicity have been found with topical diclofenac Sodium (VOLTAREN). The article lists other names of these products and explains the warning signals that may indicate liver toxicity.
Lithium Toxicity Due to Drug Interactions
January 2010
This article lists a large number of drugs, used to treat high blood pressure and other carediovascular disease, that can interact harmfully with lithium (ESKALITH; LITHOBID; LITHONATE;generic lithium carbonate), drugs used to treat bipolar (manic/depressive) disorder. This may result in a dangerous condition known as lithium toxicity because these drugs stop the body from getting rid of lithium and lithium blood levels are increased; in severe cases, this can cause seizures, coma and even death. The article also lists other symptoms of lithium toxicity.
Update on Drugs that Can Cause High Blood Potassium
December 2008
This article lists 68 drugs that can cause high blood potassium (hyperkalemia) that can result in nausea, fatigue, muscle weakness or tingling sensations, as well as heart abnormalities (showing up as an abnormal electrocardiogram). In some cases it can be fatal. If you are taking any of these drugs, be especially careful if you have diabetes or kidney disease. If so, you are at increased risk, and your doctor will have to weigh the risk of giving you these drugs. Also, the older you are, the more likely you are to develop hyperkalemia. Also, make sure you are receiving appropriate laboratory monitoring.
Comparative Gastrointestinal (GI) Toxicity of Six Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
August 2002
The British equivalent of our Food and Drug Administration (FDA), in the April 2002 issue of its newsletter Current Problems in Pharmacovigilance, published a ranking of the relative gastrointestinal (GI) toxicity of some of the widely used older nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs are commonly used for acute pain and the treatment of the symptoms of osteo- and rheumatoid arthritis.