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zoledronic acid (RECLAST, ZOMETA)

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  • Questions & Answers [hide all summaries]
    (May 2016)
    In this month’s Question & Answer feature, we respond to a reader’s request to explain why we recommend use of bisphosphonates for certain patients with osteoporosis despite our warnings about their risks.
  • A Guide to Treatments for Osteoporosis [hide all summaries]
    (May 2015)
    Drug treatment can prevent broken bones in some women with osteoporosis. But drugs are not always necessary and can cause harmful side effects, especially when treatment lasts longer than needed. Read this article to learn who should take osteoporosis drugs, which drugs to take and for how long.
  • Long-term Use of Bisphosphonates for Osteoporosis [hide all summaries]
    (January 2009)
    Emerging reports of a rare but unique type of fracture in patients receiving bisphosphonates for many years point toward the drug as a possible culprit. Unlike most drugs, bisphosphonates remain in your body for many years after you stop taking them. Further investigation into the risks, as well as benefits, of long-term bisphosphonate use is needed. But, because there is little evidence of benefit after five years and the long-term risks remain largely unknown, it is reasonable to discuss with your doctor discontinuing these drugs after five years. However, you should continue to take calcium and vitamin D supplements at currently suggested doses (discussed in the article) regardless of whether or not you are on bisphosphonates.
  • Osteoporosis Fracture Prevention: What You Need to Know about Drugs and other Measures - Part 2 [hide all summaries]
    (December 2008)
    The article discusses the difference between the benefits of drugs to prevent a first fracture (primary prevention) and to prevent further fractures in people who have already experienced a fracture (secondary prevention). In addition to discussing when it may or may not be appropriate to use drugs such as Fosamax (alendronate) or Actonel (risedronate) the article discusses ways of preventing falls and other non-pharmacologic approaches to preventing fractures.
  • Death of Parts of the Jaw Bone With Osteoporosis Drugs Such As Alendronate (FOSAMAX) [hide all summaries]
    (September 2006)
    The typical signs and symptoms of osteonecrosis of the jaw may include pain, swelling or infection of the gums, loosening of the teeth, poor healing of the gums, numbness or a feeling of heaviness in the jaw, drainage and exposed bone. Patients taking a bisphosphonate (including Fosamax) should carefully monitor themselves for any sign of jaw problems resembling those described in this article.
  • Zoledronic Acid (ZOMETA) And Pamidronate (AREDIA) Linked to Jaw Bone Damage: Popular Osteoporosis Drugs Also Evaluated [hide all summaries]
    (August 2005)
    The FDA Office of Drug Safety recommended that the professional product labeling for alendronate(Fosamax)and risedronate (Actonel) also be revised to warn of the possibility of osteonecrosis of the jaw (destruction of the jawbone). At this time, the FDA has not taken such action.

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