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Drug and Dietary Supplement Profiles

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.

Search results below include drug profiles where your selected drug is a secondary subject of discussion

drospirenone and ethinyl estradiol (GIANVI, YASMIN, YAZ, ZARAH)
We list this drug as a Do Not Use drug because it can cause increased blood levels of potassium and is no more effective than other oral contraceptives in preventing pregnancy.
moxifloxacin (AVELOX)
We list theses drugs as Do Not Use drugs because they are no more effective than similar drugs and cause irregular heartbeat.

Worst Pills, Best Pills Newsletter Articles

Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a secondary subject of discussion

Use of Tramadol for Arthritis Linked to Increased Risk of Death [hide all summaries]
(August 2019)
The FDA has approved five medications for treatment of cold sores — sometimes referred to as fever blisters, oral herpes or herpes labialis. Find out which of these drugs offer the most benefit.
Risk of Bleeding and Use of Antidepressants After Heart Attack [hide all summaries]
(March 2012)
The article discusses why taking certain antidepressants after a heart attack may increase the risk of bleeding. Find out which ones are the culprits.
Drug Mix-Ups [hide all summaries]
(June 2011)
This article lists 355 drugs with names that are often confused with similar-sounding drug names. Find out what you can do to prevent getting the wrong drug.
Liver Toxicity With Topical Diclofenac Sodium (VOLTAREN) [hide all summaries]
(March 2010)
Although skin application of drugs usually results in lower blood levels than oral use, cases of liver toxicity have been found with topical diclofenac Sodium (VOLTAREN). The article lists other names of these products and explains the warning signals that may indicate liver toxicity.
Potassium Increases Due to Drug Interactions Can Be Dangerous [hide all summaries]
(November 2008)
One of the most common drug interactions occurs when patients take two or more drugs that can each increase blood potassium levels. The resulting condition, hyperkalemia (increased blood potassium levels), can cause nausea, fatigue, muscle weakness or tingling sensations, as well as heart abnormalities, showing up as an abnormal electrocardiogram. In some cases it can be fatal. The article lists 50 drugs which, especially when used in combination, can cause hyperkalemia.
Dangers of Mixing Alcohol with Certain Medications or Diseases [hide all summaries]
(August 2008)
The article discusses 273 drugs that can have harmful interactions with alcohol. Also reviewed are several ways in which these harmful interactions can occur: 1/ Medications Can Increase Alcohol Blood Levels 2/ Additive effects of medications and alcohol. One of the best- known drug-alcohol interactions is when alcohol, a depressant, is taken with other sedative medications, and excessive sedation or depression of respiration can occur 3/Alcohol can increase the blood levels of some medications leading to toxicity of these drugs. 4/ Alcohol also can reduce blood levels of some medications causing them to be less effective. Although some of the interactions between alcohol and medications mainly occur in people who drink heavily (three or more drinks on one occasion), many of these interactions may occur with much lower amounts of alcohol use, such as one to two drinks on an occasion. We strongly urge you to tell your physicians and other health care providers how much alcohol you are drinking so they can effectively assess the risks and advise you about the safe use of alcohol and medications.
Ibuprofen Can Reduce Aspirin’s Protective Effect Against Heart Attacks and Strokes [hide all summaries]
(March 2008)
This article explains the dangers of using ibuprofen (MOTRIN, ADVIL) because it interferes with the protective effect of low-dose aspirin to prevent blood clots and protect against heart attacks or strokes. Find out how these two widely-used therapies have a harmful interaction and what you should do.
Drug Interactions: Warfarin (COUMADIN) [hide all summaries]
(December 2007)
This article explains how to understand the International Normalized Ratio (INR), a test applied to a sample of a patient’s blood to determine how “thin” it is when you are using the blood thinner COUMADIN (warfarin). In addition, the article lists more than 50 drugs or dietary supplements that can interact harmfully with COUMADIN to cause the blood to be too thin (abnormal bleeding) or not thin enough which could result in lessening the effect of COUMADIN in stopping blood clot formation.
Don't Get Sold By Drug Ads on TV, Says Study [hide all summaries]
(May 2007)
Not only does this study find that consumer drug ads are not educational, it also says that the ads may oversell the benefits of the drugs and could put the public health in danger. For example, of the 24 drugs included in this advertising study, seven are listed as Do Not Use in Worst Pills, Best Pills publications. You should not rely on direct-to-consumer television advertisements as a source of drug information.
Glucosamine and Chondroitin for Knee Arthritis - Still No Evidence of Effectiveness [hide all summaries]
(May 2006)
In the most rigorous study to date, there was no evidence of effectiveness for glucosamine, chondroitin or the two together. We continue to recommend against the use of these unregulated supplements.
Problems With COX-2 Inhibitors Vault Meloxicam (MOBIC) To Blockbuster Status [hide all summaries]
(March 2005)
There is no medical reason why you should be taking meloxicam rather than an older, equally effective NSAID such as ibuprofen to manage arthritis.
Blockbuster Arthritis Drug Rofecoxib (VIOXX) Withdrawn From Market [hide all summaries]
(November 2004)
Vioxx is the ninth prescription drug to be taken off the market in the past seven years that Worst Pills, Best Pills News readers were previously warned DO NOT USE. The average time between warning readers not to use these drugs and their removal from the market was one year and eight months.
Lawsuit Reveals Serious Safety Problems with the Nonsteroidal Anti-inflammatory Drug Valdecoxib (BEXTRA) [hide all summaries]
(September 2004)
Public Citizen filed suit in the District Court for the District of Columbia on February 25, 2004 against the Food and Drug Administration (FDA) asking that they make public complete copies of the agency’s scientific reviews of the nonsteroidal anti-inflammatory drug (NSAID) valdecoxib (BEXTRA).
Do Not Use! New Safety Warning Added to the Arthritis Drug Valdecoxib (BEXTRA) [hide all summaries]
(January 2003)
There is an additional similarity (aside from our listing both as DO NOT USE drugs) between valdecoxib and celecoxib, both are sulfa drugs and individuals who are allergic to sulfa drugs should not use them. Although celecoxib came on the market with a warning about sulfa drug allergy, valdecoxib did not. We previously wrote “It may be a dangerous oversight on the part of the FDA not to have required the same warning for valdecoxib.” Unfortunately, because uninformed patients have been needlessly harmed, our prediction has come to pass.
Arthritis Drug Rofecoxib (VIOXX) Linked to Increased Risk of Coronary Heart Disease [hide all summaries]
(December 2002)
Investigators from Vanderbilt University in Nashville TN, in a study published in the October 5, 2002 issue of The Lancet, found that patients taking 50 milligrams per day of the arthritis and painkilling drug rofecoxib (VIOXX) for longer than five days are 70 percent more likely to develop coronary heart disease (CHD) than nonusers of the drug.
Comparative Gastrointestinal (GI) Toxicity of Six Nonsteroidal Anti-inflammatory Drugs (NSAIDs) [hide all summaries]
(August 2002)
The British equivalent of our Food and Drug Administration (FDA), in the April 2002 issue of its newsletter Current Problems in Pharmacovigilance, published a ranking of the relative gastrointestinal (GI) toxicity of some of the widely used older nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs are commonly used for acute pain and the treatment of the symptoms of osteo- and rheumatoid arthritis.
Merck’s Promotion Of Its Arthritis Drug Rofecoxib (VIOXX) Crosses Legal Lines And Poses Public Danger [hide all summaries]
(November 2001)
The Food and Drug Administration (FDA) on September 17, 2001 made public a Warning Letter it had issued to Merck & Co. about a false and misleading promotional campaign that the pharmaceutical giant had been conducting on behalf of its blockbuster arthritis drug rofecoxib (VIOXX).The FDA said, "Specifically, your promotional campaign discounts the fact that in the VIGOR study, patients on Vioxx were observed to have a four to five fold increase in myocardial infarctions (MIs) compared to patients on the comparator nonsteroidal anti-inflammatory drug (NSAID), Naprosyn (naproxen)."

Additional Information from Public Citizen

Search results below include Additional Information from Public Citizen where your selected drug is a secondary subject of discussion

Strong Federal Legislation Necessary to Require Clinical Trial Registries and Results Databases [hide all summaries]
Publicly available clinical trial registries and databases of the trials’ outcomes are necessary to counteract the tendency of pharmaceutical companies to suppress unfavorable study results, according to a report released today by Public Citizen.
FDA Should Give Oral Presentations at All Advisory Committee Meetings, Public Citizen Tells Agency [hide all summaries]
Agency experts should be required to give presentations at all future Food and Drug Administration (FDA) advisory committee meetings discussing specific products, Public Citizen said in a petition filed today.
Article in Law and Contemporary Problems: Access to Pharmaceutical Data at the FDA (HRG Publication #1789) [hide all summaries]
Advocates of greater corporate involvement in clinical science argue that the public benefits from the more rapid movement of beneficial products into commerce, but progress in science is based on the free publication of study results and on the public release of data. In contrast, the governing ethic in the corporate sector is secrecy -- the withholding of any information from which a competitor might benefit.
Testimony before the Senate Special Committee on Aging on The Impact of Direct-to-Consumer Drug Advertising on Seniors’ Health and Health Care Costs (HRG Publication #1751) [hide all summaries]
DTC advertising is nothing less than an end-run around the doctor-patient relationship – an attempt to turn patients into the agents of pharmaceutical companies as they pressure physicians for medications they may not need.

Health Letter Articles

Search results below include Health Letter Articles where your selected drug is a secondary subject of discussion

No 'Alternative' [hide all summaries]
(October 2006)
Placebos are very powerful. Beyond yoga for lower back pain and acupuncture for analgesia, there has not been a study showing an unequivocal benefit of an alternative therapy when subjected to the rigor of an NIH trial. This negative outcome should not be greeted smugly, because most experimental drugs developed by pharmaceutical or biotechnology companies fail to fulfill their promise.

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