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topiramate (TOPAMAX)

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  • Illegal Promotion of a Drug That Causes Birth Defects [hide all summaries]
    (May 2011)
    Find out why Johnson & Johnson was recently criminally prosecuted for illegally promoting an epilepsy drug that clearly causes birth defects.
  • Drug-induced Cognitive Impairment: Part 2: Delirium and Dementia [hide all summaries]
    (April 2009)
    This second article about drug-induced dementia or delirium lists and discusses an additional 79 drugs that can cause these reversible kinds of mental deterioration. The two articles collectively review 136 drugs that can cause these serious side effects, especially in older people.
  • Drug-Induced Eye Toxicity: 62 Drugs That Can Cause Eye Disease [hide all summaries]
    (April 2008)
    This article, based on a recent review in Drug Safety, lists 62 prescription drugs that can cause eye disease. The range of drug-induced eye diseases includes diseases of the eyelids, glaucoma, cataracts, retinal damage and optic nerve damage. As is true for drug-induced diseases in other parts of the body, you should consider newly developed eye symptoms beginning shortly after starting a new medication to be possibly drug-induced and consult a physician.
  • Taking TOPAMAX to Treat Alcoholism Could Have Serious Consequences [hide all summaries]
    (December 2007)
    A recent drug industry-funded study was widely hailed as showing that TOPAMAX, a drug approved for seizures and migraines, worked well in treating alcoholism in heavy drinkers. However, upon closer inspection, the study does not convincingly prove the safety or effectiveness of the new suggested use of topiramate. The use of the drug produced only a modest decrease in the percentage of days of heavy drinking, compared to placebo. Topiramate can be unsafe if mixed with alcohol. Current FDA labeling for the approved uses of the drug states, “You should avoid drinking alcohol while taking [topiramate]. Alcohol with [topiramate] can make side effects such as sleepiness and dizziness worse.” In addition. the drug can cause metabolic acidosis, a condition that occurs when there is too much acid in your blood. Metabolic acidosis can cause symptoms such as tiredness, loss of appetite, irregular heartbeat and impaired consciousness.
  • The Danger of Prescribing without Proof: Examples of Prescriptions for Drugs Not Shown to be Safe and Effective [hide all summaries]
    (July 2006)
    The article discusses numerous recent examples of the harm that has been caused by off-label prescribing, including the heart drugs amiodarone (Cordarone), many antipsychotic drugs, topiramate (Topamax)and several antidepressants.
  • A Review of Seizure Medication Topiramate (TOPAMAX) for Weight Reduction [hide all summaries]
    (February 2004)
    Internet advertisements are heavily promoting the use of topiramate (TOPAMAX), a prescription drug approved by the FDA only for the treatment of seizures, as a weight reduction agent, a purpose for which it has not been shown to be safe and effective.
  • New Warnings For The Seizure Drug Topiramate (TOPAMAX) [hide all summaries]
    (September 2003)
    A warning was issued in June 2003 about the possibility of potentially serious decreased sweating (oligohidrosis) and elevated body temperature (hyperthermia) with the use of the seizure medication topiramate (TOPAMAX). Topiramate is approved by the Food and Drug Administration (FDA) for adult and child patients ages two to 16 years with certain types of seizures, and in patients two years of age and older with seizures associated with Lennox-Gastaut syndrome.
  • Serious Vision Disorder With Topiramate (TOPAMAX) [hide all summaries]
    (November 2001)
    Health care professionals were notified on September 26, 2001 about an eye disorder in some patients taking the seizure drug topiramate (TOPAMAX). This condition is characterized by acute myopia (nearsightedness) and secondary-angle closure glaucoma.
  • Review of Anti-Seizure Drugs For Bipolar Disorder [hide all summaries]
    (March 2001)
    The editors of the highly respected Medical Letter on Drugs and Therapeutics, for doctors and pharmacists, reviewed evidence from controlled clinical trials of anti-seizure drugs for psychiatric disorders in the December 11, 2000 issue. Controlled clinical trials are the “gold standard” for testing the effectiveness of drugs.

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