propoxyphene (DARVON, DARVON-N)

Drug and Dietary Supplement Profiles

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.

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propoxyphene (DARVON, DARVON-N); propoxyphene and acetaminophen (DARVOCET-N, PROPOXACET-N, WYGESIC); propoxyphene, aspirin and caffeine (DARVON COMPOUND, DARVON COMPOUND-65)
We list this drug as a Do Not Use drug because it is no more effective than aspirin and is addictive.

Disease and Drug Family Information

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Narcotics [hide all summaries]
Most of the time when someone is able to swallow, they should first try a nonnarcotic drug such as aspirin taken by mouth. If aspirin alone is not effective, it can be combined with a narcotic, such as codeine. These two drugs work in different ways, and when they are used together, they generally relieve pain that would otherwise require a higher dose of narcotic, while causing fewer adverse effects.

Worst Pills, Best Pills Newsletter Articles

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Painkiller DARVOCET Now Phased Out of U.K. Market; Still Widely Prescribed in the U.S. [hide all summaries]
(January 2008)
Why is this big-selling, extremely dangerous, not very effective narcotic painkiller still on the market in the U.S. despite haveing been withdrawn in the U.K.? Learn about how it kills more than 200 people a year.
Health Research Group Petitions to Phase Out the Sale of the Painkiller Propoxyphene (DARVON, DARVOCET, and Generic Versions) [hide all summaries]
(June 2006)
On Feb. 28, 2006, the Health Research Group petitioned the Food and Drug Administration (FDA) to immediately begin phasing out the sale of the dangerous painkiller propoxyphene (DARVON). The reason for the petition is that propoxyphene has been associated with over 10,000 confirmed deaths and 2,110 reported accidental deaths in the U.S. from 1981 through 1999. There are many generic versions of propoxyphene on the market, as well as a number of products that combine propoxyphene with acetaminophen (TYLENOL). These products are sold as DARVOCET and are also widely sold as generic drugs. A phased withdrawal, instead of an immediate ban, is necessary because of the addicting properties of the drug and the need to switch patients to other painkillers.

Additional Information from Public Citizen

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FDA Committee Vote Confirms Darvon’s Risks Outweigh Benefits, Drug Should Be Banned [hide all summaries]
Today’s Food and Drug Administration (FDA) advisory committee vote confirms that the risks of propoxyphene (Darvon) outweigh its benefits. The FDA must, therefore, remove it from the market.
Testimony of Sidney Wolfe Before Food and Drug Administration Advisory Committee on Propoxyphene (DARVON) (HRG Publication #1856) [hide all summaries]
Dr. Wolfe testifies before the Food and Drug Administration and advocates for a two-year phased withdrawal of these products.
Petition to FDA to ban all propoxyphene (DARVON) products; prescription painkiller causes many fatalities (HRG Publication #1762) [hide all summaries]
Petition to FDA to ban all propoxyphene (DARVON) products; prescription painkiller causes many fatalities (HRG Publication #1762)

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