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Drug Profiles \| Worst Pills, Best Pills Newsletter Articles \| Additional Information from Public Citizen

Drug and Dietary Supplement Profiles

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.

Search results below include drug profiles where your selected drug is a primary subject of discussion

citalopram (CELEXA); escitalopram (LEXAPRO); fluoxetine (PROZAC, SARAFEM, SELFEMRA); fluvoxamine (LUVOX); paroxetine (BRISDELLE, PAXIL, PEXEVA); sertraline (ZOLOFT)

Disease and Drug Family Information

Search results below include Disease and Drug Family Information where your selected drug is a primary subject of discussion

Depression: When are Drugs Called For And Which Ones Should You Use? [hide all summaries]
Ironically, one of the kinds of depression that should not be treated with drugs is depression caused by other kinds of drugs. If someone is depressed and the depression started after beginning a new drug, it may well be drug-caused. Commonly used drugs known to cause depression include the following:

Worst Pills, Best Pills Newsletter Articles

Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a primary subject of discussion

Drug-Induced Hair Loss [hide all summaries]
(July 2016)
For most people with hair loss, the condition usually is age-related or due to the genes they inherited from their parents. But for some patients, the cause of the problem can be found in the medicine cabinet. Learn about some commonly used medications that can cause hair loss.
Anticholinergics May Increase Dementia Risk in Elderly [hide all summaries]
(August 2015)
Learn about recent evidence suggesting that anticholinergic drugs — which include many antidepressants, antihistamines and overactive bladder control medications — may increase the risk for developing Alzheimer’s disease and other types of dementia in the elderly.
Year in Review: Troubling New Drug Approvals of 2013 [hide all summaries]
(March 2014)
Learn about new drugs approved by the FDA in 2013 that Worst Pills Best Pills has identified as dangerous or ineffective. The drugs include two for diabetes, two for chronic obstructive pulmonary disease and an over-the-counter drug for overactive bladder, among others.
How Effective Are Antidepressants for Depression? [hide all summaries]
(February 2014)
Some degrees of depression are less likely to respond to treatment with an antidepressant. This article reviews the evidence and evaluates 27 different antidepressants, labeling many as Do Not Use or Limited Use.
Do Not Use Paroxetine (BRISDELLE) For Treatment of Hot Flashes [hide all summaries]
(January 2014)
A newly marketed drug for treating hot flashes of menopause, BRISDELLE, is a lower dose of the familiar antidepressant PAXIL. This article discusses its risks and barely-evident effectiveness.
The Continuing Exploitation Of Menopausal Women [hide all summaries]
(November 2013)
This month will see the launch of yet another highly promoted drug to treat the hot flashes of menopause. Like almost all of its predecessors, it has clear risks and also lacks strong evidence of usefulness.
Settlement Not Enough to Deter Illegal Pharmaceutical Industry Behavior [hide all summaries]
(August 2012)
Find out how a seemingly large $3 billion criminal and civil penalty levied against GlaxoSmithKline — because of its small size relative to the drugmaker’s profits and the absence of jail time for any of the company’s officials — tacitly encourages drug companies to continue illegal activities.
Antidepressants and Dementia in the Elderly [hide all summaries]
(August 2012)
We review a recent study concerning the lack of evidence that antidepressants are effective in elderly, demented people. Find out the risks involved with antidepressant use in this population and learn about the safer, more effective nondrug approaches to treating depression in elderly adults.
Update on Grapefruit Juice-Drug Interactions [hide all summaries]
(July 2012)
This article updates and expands our earlier list of drugs that can have harmful interactions with grapefruit juice. The list now includes 82 different drugs.
Preventing Heat-Induced Death and Illness [hide all summaries]
(June 2012)
This article lists practical steps to take to avoid death, hospitalization or other medical problems caused by heat stress. It also contains a list of 123 drugs that can impair your response to heat.
Risk of Bleeding and Use of Antidepressants After Heart Attack [hide all summaries]
(March 2012)
The article discusses why taking certain antidepressants after a heart attack may increase the risk of bleeding. Find out which ones are the culprits.
Prescription Drugs and Increased Traffic Accident Risk [hide all summaries]
(July 2011)
The article reviews evidence that taking any of eight different classes of prescription drugs can significantly increase the risks of being involved in a traffic accident in which someone is injured. Find out what the classes of drugs are.
Antidepressants: Effective for Major Depression, Not for Minor Depression [hide all summaries]
(May 2011)
Find out the difference between major depression and minor depression and why antidepressants, which are effective with precautions for the former, are not effective for the latter.
Drug-Induced Acute Akathisia (Restlessness) [hide all summaries]
(April 2011)
The article lists 27 drugs that can cause akathisia, a condition characterized by muscular quivering and the inability to sit still. Other signs of the condition include fidgety movements, leg swinging while sitting, rocking from foot to foot or pacing and motor restlessness.
Neuroleptic Malignant Syndrome (NMS) [hide all summaries]
(December 2010)
The article describes the symptoms of the life-threatening neurological disorder neuroleptic malignant syndrome (NMS) and lists 40 different prescription drugs that have been found to cause it.
Drug-Induced Parkinsonism [hide all summaries]
(October 2010)
A study discovered that more than 1 out of every 10 people who went to a Parkinson’s disease center was found to have drug-induced Parkinsonism. These people were misdiagnosed as having the more common illness, Parkinson’s disease, which is irreversible and has unknown causes.
Dextromethorphan (DELSYM, ROBITUSSIN DM) for Cough: More Reasons to Avoid It [hide all summaries]
(June 2010)
Find out why you should not use cough products such as ROBITUSSIN DM that contain dextromethorphan. Also view a list of 22 other drugs that can have harmful interactions with dextromethorphan.
Risk of Serious Gastrointestinal Bleeding With Newer Antidepressant Drugs [hide all summaries]
(April 2010)
This article discusses the greatly increased risk of bleeding with some widely-used antidepressant drugs and provides information that the FDA has not yet required be included in the patient Medication Guides for these drugs.
Alpha-Blockers for Prostate Enlargement: Some Important Drug Interactions [hide all summaries]
(June 2009)
Taking alpha-blockers in combination with drugs for erectile dysfunction and with other drugs can cause dizziness and fainting. In this article we will discuss alfuzosin (UROXATRAL), doxazosin (CARDURA), tamsulosin (FLOMAX) and terazosin (HYTRIN) and drugs with which they can have harmful interactions.
Tizanidine: Watch Out for Drugs Interacting With This Muscle Relaxant [hide all summaries]
(October 2008)
Tizanidine (ZANAFLEX) is a muscle relaxant for which more than 3.8 million prescriptions were filled in the U.S. last year. The article lists more than 64 drugs with which it can have dangerous interactions resulting in excess sedation, difficulty breathing or dangerously low blood pressure that can result in falling.
New Report Sheds Light on Serious Safety Problems with Anti-Smoking Drug Varenicline (CHANTIX) [hide all summaries]
(July 2008)
A recent study has found large numbers of reports of psychiatric adverse effects with varenicline (CHANTIX) including hundres of reports of suicidal acts, thoughts or behaviors; possible psychosis; and hostility or aggression.
Serotonin Syndrome Due to Drug Interactions [hide all summaries]
(April 2008)
The article lists more than 30 prescription drugs that can cause the serotonin syndrome.
Drug-Induced Eye Toxicity: 62 Drugs That Can Cause Eye Disease [hide all summaries]
(April 2008)
This article, based on a recent review in Drug Safety, lists 62 prescription drugs that can cause eye disease. The range of drug-induced eye diseases includes diseases of the eyelids, glaucoma, cataracts, retinal damage and optic nerve damage. As is true for drug-induced diseases in other parts of the body, you should consider newly developed eye symptoms beginning shortly after starting a new medication to be possibly drug-induced and consult a physician.
SSRIs Can Have Dangerous Interactions With Other Drugs [hide all summaries]
(January 2008)
More than 70 million prescriptions a year are filled for these popular antidepressants, including Prozac, Paxil, Zoloft, Luvox, Celexa and Lexapro. This article gives details about more than 60 other widely prescribed prescription drugs that can have harmful interactions if used with these antidepressants. The two different kinds of interactions are also discussed.
Older Adults May Have Low Blood Sodium Levels When Using the Antidepressant Venlafaxine (EFFEXOR) [hide all summaries]
(August 2007)
Patients over the age of 65 taking or considering taking venlafaxine (EFFEXOR) should ask their provider to check for low blood sodium levels within three to five days after treatment is started. Patients taking venlafaxine who are experiencing the symptoms of low blood sodium levels listed in the article should contact the prescriber as soon as possible. Patients should not discontinue taking venlafaxine without first consulting with their prescribing health care provider. Other antidepressants in the SSRI family such as PROZAC and PAXIL have also been found to cause low sodium levels.
FDA: All Antidepressants Should Carry Warnings About Risks of Suicidal Thoughts in Young Adults [hide all summaries]
(July 2007)
Because of new information about increased risks of suicidal thoughts associated with the use of a variety of antidepressants, people of all ages should be monitored closely with all antidepressants after the drugs are first prescribed, switched or when the dosage is changed. Do not stop using any antidepressants without first consulting the prescriber.
PUBLIC HEALTH ADVISORY: Migraine Drugs, Antidepressants May Cause Life-Threatening Interactions [hide all summaries]
(October 2006)
If you are taking triptans, SSRIs or SNRIs and experience the symptoms of serotonin syndrome listed in this article, you should seek medical attention immediately. This is because of the possibility of life-threatening reactions such as nausea, changes in blood pressure or hallucinations that may be caused by the interaction of migraine headache drugs, called triptans, and certain antidepressants.
PUBLIC HEALTH ADVISORY: Continuing Antidepressants During Pregnancy May Help Mother, Harm Baby: A Medical Dilemma [hide all summaries]
(October 2006)
Women who are pregnant and taking certain antidepressants take note: a recent study finds that you are more likely to have a recurrence of depression if you stop treatment during pregnancy, but another recent study suggests that taking certain antidepressants may harm your baby. Find out about this dilemma.
The Danger of Prescribing without Proof: Examples of Prescriptions for Drugs Not Shown to be Safe and Effective [hide all summaries]
(July 2006)
The article discusses numerous recent examples of the harm that has been caused by off-label prescribing, including the heart drugs amiodarone (Cordarone), many antipsychotic drugs, topiramate (Topamax)and several antidepressants.
Paxil and Birth Defects [hide all summaries]
(December 2005)
You should consult with your doctor immediately if you are taking paroxetine and are pregnant and particularly if you are in your first trimester. Suddenly stopping paroxetine and drugs like it may result in a withdrawal syndrome. See the warning statement above.
Black Box Warning To Be Required On All Antidepressants Concerning Suicide Risk In Children And Adolescents [hide all summaries]
(December 2004)
Belatedly, the Food and Drug Administration (FDA) announced on October 15, 2004 that it is taking steps to inform parents and physicians about the risks of antidepressants when these drugs are used to treat major depressive disorder in children and adolescents.
Canadians Warned of Potential Adverse Effects of Maternal Use of Antidepressants on Newborns. American Mothers Still in the Dark [hide all summaries]
(October 2004)
The Canadian equivalent of the Food and Drug Administration (FDA), Health Canada, issued a public advisory on August 9, 2004 warning that newborns may be adversely affected when their mothers take one of the family of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) and other newer anti-depressants during the third trimester of pregnancy.
Suicide Risk Added To The Professional Product Labeling For Eight Antidepressants [hide all summaries]
(August 2004)
At the request of the Food and Drug Administration (FDA), eight out of ten manufacturers of newer antidepressants have agreed to add a warning about the possibility of an increased risk of suicide associated with the use of these drugs. The warning will appear in the professional product labeling, or package insert, for these drugs.(listed in the article)
The Antidepressant Fluoxetine (Prozac) and Suicidal Ideation — Déjà vu 1991 [hide all summaries]
(May 2004)
Fourteen years ago, in May 1991, the Health Research Group petitioned the Food and Drug Administration (FDA) to require a warning in the professional product labeling, or package insert, of fluoxetine (PROZAC) concerning the risk of suicidal impulses in patients using the drug. Fluoxetine belongs to the family of antidepressants known as selective serotonin re-uptake inhibitors, or SSRIs. Read the warning we asked for back then.
FDA Issues Public Health Advisory On Antidepressants And Suicide Risk In Children [hide all summaries]
(December 2003)
The Food and Drug Administration (FDA) issued a Public Health Advisory on October 27, 2003 about reports of suicidal thinking and suicide attempts in clinical trials of eight drugs in pediatric patients with major depressive disorder (MDD).
Drug Induced Psychiatric Symptoms [hide all summaries]
(October 2002)
This is the first of a two part series on drug induced psychiatric symptoms that is based on the July 8, 2002 issue of The Medical Letter on Drugs and Therapeutics. Regular readers of Worst Pills, Best Pills News will recognize The Medical Letter as a reference source written for physicians and pharmacists that we often use because of its reputation as an objective and independent source of drug information. The article lists the drugs and their psychiatric adverse effects.
Grapefruit Juice and Drug Interactions [hide all summaries]
(June 2002)
Grapefruit juice can interact with a number of therapeutically important drugs that could lead to the possibility of toxicity. These drugs are listed in the article.

Additional Information from Public Citizen

Search results below include Additional Information from Public Citizen where your selected drug is a primary subject of discussion

Testimony to the FDA on paroxetine for menopausal symptoms [hide all summaries]
Public Citizen strongly opposes the Food and Drug Administration’s (FDA’s) approval of paroxetine for treatment of menopause-related vasomotor symptoms (VMS, which includes hot flashes and flushing) due to the drug's questionable benefits and well-established risks.

Health Letter Articles

Search results below include Health Letter Articles where your selected drug is a primary subject of discussion

Research as Public Relations: Antidepressants and Suicide in Youth [hide all summaries]
(October 2007)
Because of evidence from a number of studies, the Food and Drug Administration (FDA) recently required a “black box” label for all SSRI (selective serotonin reuptake inhibitor) antidepressants indicating that use in children could lead to an increased risk of suicidal behavior. Now comes a study published in the prestigious American Journal of Psychiatry (Volume 164, pp. 1356-1363) purporting to show, in effect, the opposite: the FDA warnings had caused the rate of pediatric SSRI prescriptions to plummet and as a result young people are killing themselves due to lack of treatment. If this were true, it would be a clear example of the unintended consequences of regulation. The paper and its subsequent publicity appear to be little more than a public relations ploy. The editors of the AJP should not have allowed such gross misrepresentations to pass into print unscathed, and journalists who cited this study as if it deserved equal credence to the RCTs are just as guilty.
Successfully Pushing Paxil on Television [hide all summaries]
(July 2005)
A new study shows how direct-to-consumer advertising can increase the use of antidepressants for minor conditions.

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