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Search Term: dihydroergotamine (D.H.E. 45, MIGRANAL NASAL SPRAY)


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  • New Safety Warnings! Dihydroergotamine (DHE 45 INJECTION, MIGRANAL NASAL SPRAY) for Migraine Headache [hide all summaries]
    (November 2002)
    On July 31, 2002, the strongest type of drug safety warning that the Food and Drug Administration (FDA) can require, a black box warning, was added to the professional product labeling, or “package insert,” for the migraine headache drug dihydroergotamine (DHE 45 INJECTION, MIGRANAL NASAL SPRAY). The new warning involved numerous drug interactions between dihydroergotamine and other drugs that can raise the blood levels of dihydroergotamine leading to a life-threatening contraction of blood vessels (vasospasm) that can block the flow of blood to the brain and other areas of the body.

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