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Drug Profiles \| Disease and Drug Family Information \| Worst Pills, Best Pills Newsletter Articles \| Additional Information from Public Citizen

Drug and Dietary Supplement Profiles

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.

Search results below include drug profiles where your selected drug is a secondary subject of discussion

vitamin D (CALCIFEROL)

Disease and Drug Family Information

Search results below include Disease and Drug Family Information where your selected drug is a secondary subject of discussion

Antipsychotic Drugs: Dangerously Overused [hide all summaries]
Antipsychotic drugs, also called neuroleptic drugs or major tranquilizers, are properly and successfully used to treat serious psychotic mental disorders, the most common of which is schizophrenia. In younger adults, an alarming number of those with schizophrenia who could and often have previously benefited from antipsychotic drugs are not receiving them. They are seen, among other places, on the streets and in homeless shelters. In older adults, the problem is not underuse but, rather, gross overuse by people who are not psychotic.
Drug-Induced Diseases [hide all summaries]
Each year, more than 9.6 million adverse drug reactions occur in older Americans. The referenced study found that 37% of these adverse reactions were not reported to the doctor, presumably because patients did not realize the reactions were due to the drug. This is not too surprising considering that most doctors admitted they did not explain possible adverse effects to their patients.

Worst Pills, Best Pills Newsletter Articles

Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a secondary subject of discussion

Nebivolol (BYSTOLIC): Limited Use for Hypertension [hide all summaries]
(April 2018)
When the beta blocker nebivolol was approved by the FDA in 2007, we advised readers not to use the drug until 2015, in accordance with our seven-year rule. Find out why we now have designated nebivolol as Limited Use and whether it is the right choice for treating hypertension.
Milnacipran For Fibromyalgia: Do Not Use [hide all summaries]
(January 2018)
Milnacipran (SAVELLA) was approved by the Food and Drug Administration in 2009 for the treatment of fibromyalgia in adults, which remains its only approved use. In this article, we review data showing that the drug is ineffective for treating fibromyalgia and dangerous.
Spironolactone: Review of a ‘Water Pill’ [hide all summaries]
(March 2017)
Spironolactone is a diuretic (water pill) that has been used for decades to treat certain patients with high blood pressure, heart failure, swelling (water retention) and other conditions. Find out who is most likely to benefit from using this drug and who should avoid it because of its dangerous adverse effects.
St. John’s Wort: No ‘Wonder Remedy’ for Depression [hide all summaries]
(February 2016)
St. John’s wort, an over-the-counter herbal supplement, has been around for centuries, and many patients have been using it in recent years to self-medicate for depression. In this article, we explain why St. John’s wort should not be used to treat this disease.
The New Diabetes Drug Canagliflozin (INVOKANA) [hide all summaries]
(February 2014)
Do not use the newly approved diabetes drug INVOKANA. It offers no benefits over existing drugs but can result in serious risks, including hypotension and impaired kidney function, outlined in the article.
Drug Mix-Ups [hide all summaries]
(June 2011)
This article lists 355 drugs with names that are often confused with similar-sounding drug names. Find out what you can do to prevent getting the wrong drug.
Massive Misprescribing of Inappropriate Drugs to Hospitalized Elderly Patients [hide all summaries]
(September 2008)
A nationwide study published in spring 2008 in the Journal of Hospital Medicine showed that nearly half (49 percent) of almost 500,000 hospital patients older than 65 have been prescribed one or more of 92 drugs known to be unnecessarily unsafe for older patients. 10,000 of these patients had four or more of these inappropriate medicines prescribed during their hospitalization. Among the most common categories of adverse drug reactions these inappropriately prescribed drugs can cause are excessive sedation, abnormally low blood pressure and bleeding. We list the 92 drugs in the article and give further details about the kinds of side effects these drugs can cause.
Calcium Channel Blocker Drug Interactions [hide all summaries]
(May 2008)
This article lists more than 60 prescription drugs that can interact with calcium channel blocking drugs such as amlodipine (NORVASC),diltiazem (CARDIZEM, DILACOR XR TIAZAC)or nifedipine (PROCARDIA)to either cause toxicity or to lessen the effectiveness of the calcium channel blocking drugs. Included in the lists are a number of drugs that we list in Worst Pills, Best Pills as DO NOT USE or LIMITED USE drugs. The article also explains the different kinds of toxicity that can ensue from these interactions.
Macrolide Antibiotic Drug Interactions [hide all summaries]
(February 2008)
The article discusses the adverse drug interactions between either of two widely-prescribed macrolide antibiotics, erythromycin (as in ERYTHROCIN) and clarithromycin (BIAXIN)and more than 40 other drugs that are listed in a table in the article. It also describes the nature of the adverse interactions that can occur.
Adverse Drug Reactions Cause 1.4 Million Emergency Room Visits in 2004 and 2005 [hide all summaries]
(January 2007)
An estimated 701,547 patients were treated for adverse drug reactions in emergency rooms each year in 2004 and 2005, totaling 1.4 million visits to the emergency room. Of these, an estimated 117,318 patients were hospitalized each year. According to the study. 18 drugs were each, either independently or in combination with other drugs, implicated in one percent or more of the estimated adverse drug events. These drugs are listed in the table that accompanies this article along with the annual estimates of adverse drug events.
BIDIL, a Heart Drug Targeted at African Americans, Stirs Complex Controversy [hide all summaries]
(September 2005)
You should only be using BiDil for congestive heart failure in combination with other drugs for this condition. For one-fourth of the cost, with the cooperation of your physician, you can get prescriptions for the two generically-available drugs that comprise BiDil, isosorbide dinitrate and hydralazine.

Additional Information from Public Citizen

Search results below include Additional Information from Public Citizen where your selected drug is a secondary subject of discussion

Comments submitted on FDA Guidance for Industry on Clinical Lactation Studies (HRG Publication #1735) [hide all summaries]
Comments by Elizabeth Barbehenn submitted to FDA Guidance for Industry on Clinical Lactation Studies (HRG Publication #1735)
Statement before the National Academy of Sciences on the Framework for Evaluating the Safety of Dietary Supplements (HRG Publication #1594) [hide all summaries]
Since at the heart of this problem is the irrational legal distinction that has been made between those pharmacologically active chemicals which are regulated as prescription or over-the-counter drugs and those which others call dietary supplements which I call drug supplements, eventually the same standards for safety and effectiveness must be adopted.
Letter to the FDA concerning the United Kingdom's Committee on Safety of Medicine's recent warning about potentially serious drug interactions between St. John's Wort and a large number of other drugs. (HRG Publication #1513) [hide all summaries]
British physicians and patients are now being forcefully warned, for many more drugs than American physicians or patients, about potentially serious, clinically important drug interactions between the unregulated herbal St. John's Wort (Hypericum perforatum) and a large number of prescription drugs.

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